How Traumatic Brain Injury (TBI) Affects Brain Cells - New Research Could Lead to New Treatments

Each year about 1.5 million people in the U.S. survive a traumatic brain injury due to a fall, car accident, or a sports injury, which can cause immediate and long-term disability, and neurodegenerative diseases, such as Alzheimer's Disease.

University of Maryland School of Medicine (UMSOM) researchers wanted to better understand what happens in the brain during injury, so they conducted a study in mice to determine how different types of brain cells in mice react to severe trauma. The recently published results could lead to new treatments.

The University of Maryland School of Medicine serves as the anchor for a large academic health center which aims to provide the best medical education, conduct the most innovative biomedical research and provide the best patient care and community service to Maryland and beyond.

#traumaticbraininjury
#neuroscience

[jonkas]

At 21 I hit my head hard. 45 lbs intracranial pressure. Took years before I could read a page in less than 15 minutes. Mid twenties I fell into the machine shop industry. People would get in my face and scream at me when I asked them to repeat instructions two or three times as I struggled to process information. Now I'm 52. I do my job well. People come to me to solve problems. But I still struggle. It's like traveling in my own lane, at my own pace. To merge with the traffic has been too difficult. I live this life as best as I can for myself.

[VirginiaSwann-pnkf]

Had a TBI, 2 Skull Fractures and In A Coma for 6 weeks and 3 days at Baylor Hospital Dallas Texas in 1974.
I'm 60 years old and suffer from GAD, Panic Attacks, Depression, PTSD, Total Memory Loss Prior To Wreak, Headaches Everyday unless I take my Headache Medicine From Neurologist and Paralysis on my left side for 13.5 mths.
I've struggled with my life ups and downs since the wreck.
Where I was hit by a DRUNK DRIVER ON BIKE AND MY BODY WAS UNDER HER CAR FOR 500 FT.
MY BODY LOGGED BETWEEN UNDER CAR AND MY BICYCLE.
HAD BLEEDING FROM MY LEFT EAR, MY NOSE AND MOUTH.

HAVE ANY QUESTIONS ANYONE.
I'D BE HAPPY TO HELP IF I CAN...
GOD BLESS YOU ALL
VEE...

[MrKalsandhu]

I had brain injury and concussion three years ago and feeling it’s improving every day

[tinman]

Living with brain damage is a real suffering course because there is no escape, not even a moment's respite. It follows you everywhere like a shadow, even in your dreams where it takes the form of bizarre personifications and strange, broken landscapes.

[datsuntoyy]

They'd love me. I've had 10 concussions, 3 skull fractures and knocked unconscious 5 times. 3 years ago I had a stroke to further compound the situation. Memory issues, depression, mood swings, anger issues, balance problems, concentration and learning problems.

[Dom.Perignon]

I had my severe tbi when i was 20 from mva, 35.5yrs ago. Frontal & temporal lobe injury; glasgow 5 on presentation; up to 7 within 24hrs. 3wks coma, chronic mental, pysch, physical pain. I've learned to walk, talk, move, think, interact, go back to school, graduate college, work full time, wife, kids, house... pressure, stress, anger, etc... keep going a million mph... lose wife, house, kids, severe depression, anxiety, hate work, life... i've always felt that i probably have a greater chance of dementia/alzheim as i age... in a sense i've accomplished a significant amount considering the place i came from, but i couldn't manage to maintain it... it all got too much and i ended up losing it... was it worth my working so hard??? i'm near the end of the show (will be 56yrs old) and wonder how much more i can go on... i'd like to eventually donate my brain to research

[MissSkyeDoll]

I had a TBI when I was 3, I’m 31 now. Would love to see a head scan & talk to a specialist.

[Corrieri]

I was in a motor vehicle accident in 2005 at the age of 20 and collapsed the whole right side of my brain. I have struggled with memory issues along with anxiety and severe depression ever since. I have worked the whole time since the accident and my anxiety and seizures have just gotten to bad and i have 38 of the 40 credits needed as well as 20 years of medical records and they still are denying me. I am awaiting my appeal now and can't find an attorney because i filed everything myself. When i see the judge it will have been almost 30 months.

[jamesdemoruelle]

In someone tried to steal my car and punch me really hard. And I fell backward in a parking lot onto the cement. And my head cracked open. I lost almost all my blood and I almost died.
But had surgery end. Recovered quite nicely. I hope no long term effects now

[bradbrowne]

One year for me since my TBI last May ‘23 I was 24. I was in a coma fully brain dead for 2 months craniotomy then cranioplasty 4 months later 40% of my skull is PEEK (thermodynamic plastic). I’ve been back in work since January and the only side effect I cant kick is the tiredness and anxiety

[CubeAnimator]

I survived 3 nuclear bombs while having brain damage, got shot, got electrocuted, got burned and ran over 12 times by a drunk driver. Now i lost all my limbs and is still walking to this day.

[skylerplumb]

When I was 19 I hit my head in a car wreck and was in acoma for a month. I woke up blind in one eye no sense of smell and the front of my skull was removed. Now I barely remember anything and nothing is the same. And now I'm 30.

[Idontknow-tzlw]

When I got hit on the head with barbbell, I don't know if I had concussion or not because I didn't passed out or vomit instead I my head bleed so much. For the first months I had PTSD symtoms and very painful headeache on the area I got hit the most which is the right side. the very prominent effects of my head injury is I got severe headeache everyday, eventually the headeache reduced to a few time a month and now I only got that headeache when I got stressed.
The least prominent but very noticeable to me is I can't get focused like I used to be. I got diagnosed as an autistic kid when I was 2 or 3 years old, when it came to school assignments and chores I would always do it one time and I used to have social anxiety. After I got that head injury, I neglect my college assignments and chores and I do it when it was near the deadline or if really need it to. I tried to get assignments done with music for adhd people and it only helped me for the first few times, I tried cigarette same case, I ended up focus enhancing drugs from drug store but still the same case. I would say this effect of my head injury stil persist even after 3 years, I would like to get diagnosed for ADHD beause of the similar symtoms. I don't know if this effect was also because mental trauma I had after that head injury. Well I guess I just need to wait it up
😕

[Karin-qvmq]

You're doing great! Stay positive

[kellyroup]

At 11 years old I had a pony kick me in the head and folded back a piece of skull about 2 inches in diameter on my right temple. I survived it and even got to look into my head with myoms compact mirror before they closed and stitched it up..
Then in about 2017 I was working on my porch/deck and had stood up a 12 foot 4x4 and then forgot about it and I walked about 5 feet away to dig a hole for another post. While I was digging the post I had stood up fell over and knocked me to the ground. It caught the rest right side of my head giving me what I know now as a severe concussion. My wife and I lived by ourselves and we're pretty independent so when this happened she got the garden hose and helped me to wash the blood off my head and finally got it to stop bleeding. The cut was about 7 inches long and she wanted to take me into the hospital but seeing as I was standing and talking to her I said that we would just bandage it up and I had long hair so I had her tie it together like stitches and after a bit I finished digging the hole and nailing up that freaking 4x4 then went to take a shower because I still had quite a bit of blood on me. When I got into the shower I tried to wash out the cut and when the water hit in the cut I couldn't remember anything but she found me kneeling in the shower just rocking back and forth and she helped me snap out of it and got me standing again. It healed with the help of some herbal treatment that I made myself at the time with mullein but now years later I think I'm having issues because of it.
4-5 years after this I was watching TV and I can't tell you what show it was but all of a sudden I had tears streaming down my face! I shouted at her and she came running in to see what was wrong and I remember the look she gave me because I rarely saw that look of fear and confusion. She asked what happened and I told her that I didn't know, ! I just started crying! This time, not knowing what the issue was I agreed to go see the doc.
When I did and he asked me if I'd hit my head or something and I told him about it and he felt it he got all pissed off and said that I should have went in and had it looked at then. He was used to us and knew we generally doctored ourselves and agreed that many times that was a good thing but explained how this should not have been one of those times and that perhaps this caused my tears because of pressure but said that nothing could be done about it since it was already healed solid now.
Know I have shortness of breath issues and the years happen a couple of times a week and I get these tense moments which I guess could be considered panic attacks yet no reason for any panic.
I'm wondering if this breathing problem could be related to that and if anyone else has had this issue.
I don't as far as I know have any type of personality changes but she passed away and I'm kind of a loner now so maybe I just don't see it. I can talk to people all day when they're around but when they leave I really don't miss them and can spend several weeks alone literally enjoying the MY TIME! LOL
But I'm trying to simply find out if this could be the cause of my breathing issue because I've been to the doctor many times now and just gave up and am using herbals to treat a possible lung infection with no real success but I had no success )o

[danielsykes]

I'm glad we're learning these things, but I'm starting to feel bad for the mice

[stuartjones]

A few bad concussion in my life mixed with longcovid in 2020 and I am haveing a lot of trouble. Its difficult to simply make dinner or remember how to work with a power tool. ❤

[psychfred]

Fasting, walking, red/infrared light got about 70% back after TBI hit by car.

[juanalderetedelapena]

i sustained my tbi 4 years ago and i am afraid of future issues

[GODWinnsAmen]

I fell off a flat roof when I was 6. Hit concrete on my forehead. Cut my head open in two places. It was in 1967. Just sewed me up and parents took me home. Ace bandage wrapped around my head. The worst headache I ever had. Couldn’t learn certain things. Had a really bad temper too. Be never been the same unfortunately. Self taught guitar because I cannot comprehend learning music. I learn things but over time it’s like I never did. Went to college to study Golf course and Landscape technology. Life has been difficult but I’ve managed to survive lol. I believe in our Creator very much and that keeps me grounded. I feel better these days because this world at this time has gone absolutely nuts. I’m now 63. I only had one migraine in my life and have never actually had a headache since.