DNA repair and mutations as targets for personalised therapy

Prof Szallasi speaks with ecancertv at EACR 2016 about disrupted DNA repair pathways in cancer that may be targeted by therapy.

He summarises the mechanism of DNA repair in healthy and mutated cells and his work with next-generation sequencing of biopsy samples to uncover the origins of disease states, and how this can inform treatment selection.

With specific example of BRCA mutations, Prof Szallasi considers how genomic data are part of personalised therapy, and can contribute to new drug discovery.