mTOR Activation, Autophagy Impairment and ME/CFS

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Dr. Avik Roy and Dr. Gunnar Gottschalk from Simmaron Research present on their forthcoming work enabled by a recent R21 grant.

(NIH Advocacy Call, May 1, 2023)

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Fwiw - I have MEcfs and am a responder to rapamycin, an mToR inhibitor -- it has increased my exertion ability and when I do get PEM, it is less intense and shorter duration. I initially took 1mg daily - it look less then a month to notice effects - currently take 1mg 3x week.

medicalerrorinterviewspodc
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Thanks for uploading this, the findings are very interesting, this could have some legs to it.

bsb
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1 min on the treadmill would have had the same results. Pushing mice for 15 mins is normal even for wild mice.

brobinson
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I have severe bedridden ME/CFS and I know what severe suffering is like. So hearing you are inflicting it on innocent mice is disturbing. Animals aren’t objects. They are sentient conscious beings that will suffer too.

Over 90% of animal models for drug research fail before human trials.

Please use the mini organoids instead, you can even link multiple mini organoids representing different tissues and organs together. Stress and test that system instead. As no animal testing and suffering needed

brobinson