mTOR Signaling Pathway: mTOR Complexes, Regulation and Downstream effects

An in-depth lesson on mTOR signaling pathway, looking at both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), a brief overview of the regulation of the mTOR pathway and the many (many) downstream effects of the mTOR pathway.

Hey guys! In this lesson I give you an in-depth, detailed analysis of the mTOR pathway, starting with what the mTOR complexes are composed of, the intricate regulation of the mTOR pathway and what the mTOR pathway does including up regulation of protein synthesis and suppression of protein degradation.

WARNING: This video is not for the faint of heart - there is a lot of information in this video!

Hope you all find it helpful.

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)

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JJ

[nyoubelieve]

Was searching the web for information on Epilepsy. I was diagnosed about 3-4 years ago. Since then my understanding of my brain has baffled me. I opted out for surgery, it's not under control even with medication throughout the day. I view knowledge is power & thank you for putting everything in a way I can comprehend. I was also diagnosed with short term memory loss. My Doctors all said it's normal to loss your memory sometimes, I like to think they are Quacks with a good paying job. But have to realize they know far more then I do. Thanks for the information. Made all that fancy talk my Doctors do make some since. 😜 Will be looking forward to watching more of your posts. Thanks Again

[jhajiya]

Thank you so much genius Your all lectures are much more detail and simple explanation I am from India 🇮🇳 really salute to you ❤❤❤❤❤

[scottunique]

Once again you're in depth explanation shed light on the complexity of cellular metabolic regulation. I particularly enjoy your side comments relating to other aspects of cellular control up stream, because they give me a look into the grander scheme of life processes.

Keep up the excellent work JJ!

[maximilianUTU]

Fantastic, JJ, thank You so much!

With this video even an old brain like mine could easily understand the complex interactions and dependencies of those pathways.

Wonderful, I surely will become a JJ-addict.

[InquilineKea]

8:40 was the most importance sentence

also after so many years this was the FIRST day I understood the entire diagram...

[bpandit]

Awesome job on this JJ, I have been trying to learn how mTOR gets activated/inhibited and the things it does, and you do a stellar job of explaining this.

[kylekrantz]

I thought I was weird for checking this out for fun, then I see it has 88k views. Good to see all the other freaks and geeks

[deliberatepractice]

22.08.04. mTOR Signaling Pathway: mTOR Complexes, Regulation and Downstream effects
mTOR actually upregulates ATF4 to increase expression of MTHFD2 (purine synthesis) (Ben-Sahra et al., Science, 2016). I will correct it in the video. I'm very sorry for the mistake - hope it didn't make things too confusing :)

[cathyli]

Thank you for the really clear introduction that makes the complex signal network easier to understand!!!

[Makgeulli]

Thanks for explaining everything. I have Tuberous sclerosis complex and I’ve been wondering about what it affects in terms of genetics, so understanding how it normally works is interesting to see and fun to learn

[zkcoach]

ur channel is perfect. thanks for your effort.

[doctorhim]

Thank you so much for these videos on Cell signaling. I had a hard time trying to understand these mechanisms. You made a superb job. Now everything is crystal clear to me.
How did you collect all sorts of info? Can you please provide me some reference books on those cell signaling pathways? It would be so much helpful.

[dena]

I find this on the day of my exam... I seriously should have checked youtube for cell signalling lessons

[benarfasara]

Thank you for this video i had trouble understanding mTOR and how is it related to autism and all my teachers had no idea about it.
Thank you so much it's really well explained.

[abvmoose]

Thanks for uploading this, really good stuff.

[RainBow-xjvq]

amazing presentaiton, thank you for this

[KenzyFarid]

you are wonderful! very simplified, and beneficial. thanks too much

[rajaneshcmcg]

Is there a software or application or website which allows the creation illustratons of such pathways? It would be really be helpful if someone was able to provide the info

[annazhai]

Hi, amazing video! And I am wondering would you please share the ppt? thx!

[eliuq]

Its many pathway activation are super interesting foe building muscle, i love L Argining, also Adenosine Disodium Apt and 5G of Leucine