Pharmacology - Local Anaesthetic

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[JJay-sbcu]

I was gonna switch to another video cause I thought you were speaking a different language. And then you went LO-CA-L AN-AS-THE-TICS

[paulohenriqueluizdefreitas]

Thanks Armando! I am using your video in a lecture for dental undergrads in Brazil right now!

[cancel]

Thank you for explaining everything so patiently!! :D

[sammir]

Jesus man thanks ! Liked and subscribed!

[lozzylovesdoughnuts]

why does the weak base become ionised when the pH becomes slightly acidic?

[positivevibes]

So what's the physiology behind resting, activated and inactivated state of the channels ?And is it right that local anesthesia have low affinity for resting state of the channel and more affinity for activated state?

[ghfutjt]

May I know why hypercalcemia and hypokalemia antagonize local anesthetics?

[TaiganTundra]

In the beginning you were talking so fast I thought you were speaking Turkish.

[praspurgh]

quite a bit information, more than what I have learned in a 40 min class

[emilyprather]

This is a great artistic overview of local anesthetics and a great tool for us visual learners.  I especially appreciated how the local anesthetic being ionized was illustrated due to the acidity of the inside of the cell membrane.  This is an important first step (that I didn't understand in the reading of my textbook) in stopping pain by blocking the sodium channels (preventing sodium entry into the neurons), and stopping the action potential from propagating down the neuron. 

[QuickMedic]

I wish I could draw to your standard! Excellent overview of local anaesthetics. I refer my students to this when they want a good visual aid.

[ruthusr]

God!! You just simplified 2-3hrs in 13 mins!!!
Highly appreciated. Great job. Can't thank you enough. Keep making more such videos. More power to you. 😁

[mattnewland]

That brain u drew is so good how u do that!

[brittnyy]

you are helping so many Nursing and Doctorate students with your hard work and contributions! Thank you and keep up the great work!!

[Ericpercent]

I am a dental student, and you really explained that well, Thank you!

[timothyferris]

I'm revising Clinical Pharmacy at the moment for exam and these videos are absolutely brilliant! Its as if they're taken straight from the Rang and Dale text book! :)

[eliassiraj]

this man doing this videos is just AMAZING! THANK YOU SO MUCH FOR WHAT U DO AND MAKING THINGS UNDERSTANDABLE AND ENJOYABLE!! YOU HAVE SO MUCH INFORMATION TO SHARE AND I APPRECIATE YOU!

[mrbishopstrong]

ur a legend!!!! I was wondering wat my lecturer was goin on about when it becomes ionised within the membrane... cheerz

[shayanZZZ]

Students also should know that LAs are divided into 2 groups.Ester and Amide.each group has its own drugs

[HungarianSarah]

And it's often given with epinephrine to make the effect longer and reduces the toxicity! Sorry to make 3 comments I didn't mean to it just sent it by itself :))