Gq Pathway Of G-Protein-Coupled Receptors Explained | Clip

Welcome to Science With Tal!

In this video, we will cover the Gq pathway of the G-protein-coupled receptors (GPCRs). The Gq pathway is very important to understand, as it mediates many intracellular cascades in neurons and other types of cells. Through this discussion, we will discuss protein kinase C (PKC) and calcium-calmodulin dependent kinase (CaMK), which are 2 very important kinases in the body.

This conversation on neurons in the CNS derives from important concepts that are described in two previous full discussions:

To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.

TIMESTAMPS

0:00 Introduction
0:15 Gq pathway (PLC, PIP2, PKC, CaMK)
4:16 Word on CaMK2
5:04 Summary of Gq pathway
6:08 Conclusion

RESOURCES

Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)

- Dale Purves: Neuroscience (6th edition)
- Eric Kandel: Principles of neural science (6th edition)
- Lodish: Molecular Cell Biology (9th edition)
- Niswender, Colleen M, and P Jeffrey Conn: Metabotropic glutamate Receptors: physiology, pharmacology, and disease
- Bünemann, M et al: Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
- Howlett, Allyn C et al: CB(1) cannabinoid receptors and their associated proteins
- Morris, R G: D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949
- Stent, G S: A physiological mechanism fo Hebb’s postulate of learning

To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.

CREDITS

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond

[katiejenkins]

Thank you so much, this is so much easier to understand than trying to read papers to figure out what this pathway is and what it does. I really appreciate the work that went into this!

[evaanjos]

Your videos are my favourite for learning these concepts! Not only is the explanation super clear, but the visual graphics really help integrate it all after class.
Keep doing what you're doing :)

[caelum]

Thank you so much! I watched the lecture that our professor sent us, and I didn’t understand any part of it. It only made sense to me after I watched this video. The animation made it really easy to follow as well. Again, thank you! <3

[helennni]

❤❤🎉🎉 I finally understood this pathway without any problem I really appreciate your work 💎

[charmanteb]

You have been so helpful with explaining the GPCR pathways. Thank you, tremendously!

[tonyjiang]

Great video, thanks Tal! I have one question: for the Gq pathway, does G beta-gamma involve in signaling like G alpha?

[anjalichaurasiya]

Your channel deserves more subscribers, your work is really great keep it up 🤍

[hannahbarnes]

Doesn't PiP3 stand for phosphatidylinositol 4, 5 BISphosphate instead of BIphosphate since the phosphate groups are on different carbons? Same with inositol 1, 4, 5 TRISphosphate.

[mememamomuu]

What does the q in Gq protein stands for?? In Gi “i” is inhibiting and in Gs “s” is stimulating. I can’t find information anywhere…