Phospholipase C - IP3, DAG Pathway || Gq protein pathway

Video Summary:
Binding of a ligand with Gq protein-coupled receptor causes release of GDP and binding of GTP. The α subunit then dissociates and activates phospholipase C. Phospholipase C degrades PIP2 into IP3 and DAG. IP3 goes to the endoplasmic reticulum and opens the Ca channel. Released Ca binds with calmodulin. Ca-CaM complex alters the activity of downstream enzymes for example MLCK. DAG activates PKC which modulates the activity of other proteins like MARCKS proteins and transcription factors.

🎞 More videos on Signaling:

● Follow me at:

Dr Vipul Navadiya

DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[siddhimaliwal]

Sir, you are AMAZING!!! No words...starting from the basics, linking videos in the i-button, summarizing in the end...Questions are solved before being created in our minds. Hats off to your efforts!

[mattissteenweg]

Man i love this guy, makes all the more difficult subjects easy to understand and entertaining to watch. I hope you are doing great nonstop neuron!

[jaaml]

I am from iraq and this is the best explanation that i ever seen

[sivapriyapratheep]

So Far the best video on this topic I’ve watched❤

[MusicLyrics-gfoy]

You're the best🥳45mins lecture in 5 minutes with better understanding 🙊🙊🙊

[seldomvlogger]

What a great explaination with the animations, thanks a lot. Understood the processes very well

[maia-sage-moon]

Saving my cell bio grade!! Thank you for these videos

[sudhabhattarai]

Thank you so much for this video. This made really easy to understand. I felt like gaining knowledge while watching caartoons. 💛💛
Please we are waiting for more videos. Keep it up. 👍👍
At last again thank you so

[codeblue]

Great and simplest explanation i have come with so far, More videos on cell signalling and molecular biology please 🙏🙏🙏

[melomane]

Thank you very much sir i could digest the concept 😊😊😊

Your channel is gift of God ✨

[wycliffenyandika]

That helps, been trying to understand it for far too long and finally I got it !
Hope you have more for other stuff like genetics 🧬

[shifakhan]

U made this concept very easy and in understandable manner..we really wait for ur next videos👌👍 and really thnku very much 😊

[Alrashed.]

Thank you so much for this video is very helpful 💗

[.yt]

Wonderful video sir. I learned a lot, all doubts have cleared. Thank u very much

[MohamedMahmoud-uifg]

amazing! thank you for this beautiful explanation

[imrannazir]

best explanation
it helped me through my presentation a lot .
thank you ♥️

[louiskerkhofs]

This is trully a masterpiece! Thank you for explaning it so well!

[FD-rtrv]

great explanation, my expensive prof cannot do 1% of what you did

[dk]

Thanks a lot for this informative session

[AK-jtcc]

this is the mechanism of action for norepinephrine on the alpha 1 receptor, .. correct?