Male sex hormone system: how it works, testosterone, low T symptoms, TRT, and more | Peter Attia

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About:

The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 60 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.

Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.

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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.

[MonerBilly]

"I didn't need to draw two of them "...the hell you didn't

[ThePearguru]

This information is great, I'm so happy that content like this is free

[absbi]

Been needing an overview like this. Thanks Dr. Attia.

[AllThingsStrength-emyw]

Great video. Thanks for being clear and concise.

[vplus_]

One of the best videos on the topic if not the best 👏👏👏

[RushCooking]

Thank you, Peter. This was super helpful. I'm debating whether or not to start TRT and I feel much more informed now and ready to take action. Keep these videos coming!

[nicholascasal]

I've been looking for something exactly like this. Thank you, Dr. Attia!

[Zoe.TheBody]

I think the subtle role of progesterone in men is important and like in women it counteracts the anabolic effects of the stimulating growth effects of estrogen on the cells. Men like women today are stressed leading to lower progesterone causing relative estrogen dominance and the potential for consequences perhaps of cell proliferation and it’s role in prostate cancer. Would love your thoughts Peter? Super helpful videos. Thank you

[stevehougom]

Excellent one of the best explanations of this system Ive seen. I would like to know what you think about fasting and its affect on SHBG and androgen receptor sensivity. Also what are your thoughts on Enclomiphene instead of clomid? Thanks dr attia!

[philipsmith]

Brilliant summation for the average person trying to understand this process 👍

[lennydaiglejr]

I am 60 years old, have never HRT; my total testosterone is in the 700s with normal free and available.
My estradiol is very low; a high sensitivity test shows it to be 10 pg/ml. I am having symptoms that may be related.

My question, do some men aromatize poorly and if so is estradiol ever supplemented?

[GregGoetz]

Ridiculously good summary. (Im a physician also)

[fredbongiorno]

I think it’s more of a sensitivity to DHT at the follicle rather than hyper active 5aR which contributes to hair loss hence there’s a pattern.

[neechee]

@Peter Attia MD I think you should address the primary vs secondary hypogonadism as a fundamental underlying need for TRT in the first place and how these two diagnoses differ. The American Association of Clinical Endocrinologists is a good source . Also, I am surprised that you did not explain the two isomers found in clomid and the differences in their effects and effectiveness. Both clomid and enclomiphene are being prescribed under the umbrella of TRT.

[Yaseen_Khaliq]

Great video Doc, Can you do a video on a natural supplements you can take to boots you LH, FSH ? Thanks

[xalian]

Can you please deliver information on major mood disorders including BP1, 2, and cyclothymia. Some approaches, vitamins, and methods can cause issue. Anything to move the conversation forward as these people must live their lives too

[mac]

I was on TRT for 5 years and it caused me heart arrhythmia and finally stopped.
Years later I fixed my sleep apnea and my testosterone shot up.
Now I'm 70 and have very good testosterone levels.

[davidkerr]

This is the clearest video I've ever seen on testosterone in men. Bravo and thank you.

I've been looking into TRT for well over a year, waiting because of the lifetime cost and getting my thyroid levels right first. I have symptoms: near zero libido, fatigue, "oomph". Recent blood results show improved free T perhaps as result of increasing my activity level a lot. Next is to introduce resistance training alongside running and swimming.

Thanks again. Subscribed.

[HealthWyze]

It's good to see a doctor that gets it right.

1. First do no harm.
2. The patient matters, not the numbers.

[wesleychapman]

What amounts of Free Testosterone would be considered low, medium, high?