Highly-efficient and -specific genome editing with Cas9

Presented By: Jacob Lamberth

Speaker Biography: Jacob has been working on developing and testing Cas9 products in the Genome Engineering team at MilliporeSigma since joining the company in 2015. Recently he has focused on the development of multiple Cas9 Ribonucleoproteins and their potential therapeutic applications.

Webinar: Highly-efficient and -specific genome editing with Cas9 nickase ribonucleoproteins in Primary T-cells

Webinar Abstract: In this webinar, we will be discussing some of our most recent testing using our Cas9 proteins, Cas9 RNP nickases in a variety of human cell types, including primary T-cells. Cas nucleases when delivered in protein format, pre-complexed with a single, modified guide RNA (gRNA), rather than encoded on a plasmid, allow researchers to bypass the historically limiting factors of using CRISPR in the therapeutic realm of off-targeting effects, low efficiency, and undesired cellular responses to foreign DNA.

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