Nicotinamide Riboside vs. Nicotinamide Mononucleotide - dosing and effects on NAD+ | David Sinclair

Two NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, have been shown to ameliorate age-associated diseases in animals. They are well-tolerated at high doses and effectively raise NAD+ levels. Evidence suggests that these molecules, often referred to as "NAD+ boosters," may increase levels of NAD+ in humans, too; however, the doses used in some of the studies equate to far less than what was provided in the rodent studies. Currently, only nicotinamide riboside has been shown to raise plasma NAD+ levels and may possibly have beneficial health effects in humans. Future research, focused on "super boosters," may have relevance for treating complex diseases such as diabetes, heart disease, cancer, and Alzheimer's. In this clip, Dr. David Sinclair discusses the current state of research on the NAD+ boosters nicotinamide riboside and nicotinamide mononucleotide.

Original episode published on Nov 6, 2019
⏳ #Aging #Resveratrol #Epigenetics 🧬

About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California. She has done extensive research on aging, cancer, and nutrition.

It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.

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[garroshhellscream]

people, only take what you can afford..if you try and go all out with powders and supplemts and end up broke and homeless i can assure you that stress because of your financial problems will cause rapid aging... so just stick WITHIN your means..besides, consistancy is key.. then when you get more money you can buy more suppliments.

[UHFStation]

Could really use more comfortable chairs.

[DUDIDUAN]

NR is more efficient because of its molecular mass and size

[ster]

Can anyone give a layperson the upshot? Are they saying that there is new evidence that taking Elysium and TruNiagin at the recommended doses is now suspected to be ineffective?

[RobT]

Are we wasting $ taking 600mg of NR daily?

[christopherellis]

This is really good to hear, because I have been wondering if the present NMN &c mode is the best option,

[janetatum]

What about Ovasitol aka inositol in specific ratio (different configurations of inositol molecules)...as effective as Metformin in studies for PCOS. Does it also boost NAD+ if works like Metformin??

[defaultHandle]

We need more clarity on NR vs NMN and whether the whole slc12a8 allows NMN to be transported into the cell. Update from Sinclair is needed at this time based on new studies which he himself posted soon after this video was shot. Can someone make test kits for NR, Nicotinamide and NMN.

[Lennythewinner]

What about sublingual formulations?...

[kavorkafanstar]

So, are we still thinking Elysium is the best choice for boosting NAD? I understand resveratrol may, but it hasn't been IBS friendly to me. Nor broccoli sprouts which is more NR than NMN, correct?

[hanig]

Too expensive to take these large doses of NR or NMN for the rest of your life .I doubt serious studies will show life extending properties of either one .Supplement companies will take in big money for now until the next big thing comes along .The only fountain of youth is genetics, diet,exercise,and luck,

[bonfynil]

why does it have to be nicotinamide riboside or nicotinamide mononucleotide? Wouldn't nicotinamide have similar effects?

[guyedwards]

I'm looking for info on why NMN is better to consume than standard Nicotinamide? Any help?

[bogdanfutera]

She is talking far to much for my taste. Is that interview or rather monolologue ? David Sinclair is - in my view - not allowed to speak freely.

[pedecia]

For an Amazing Arterial Function and Endurance eat a plant based diet low in fat not oil. You will see magic happening... At 43 I reversed my arterial age to a 19 years old young man just with a diet extremely low in fats and of course without dietary cholesterol. The test used to check my arterial age was the PWV test (Pulse Wave Velocity test).