What is GLP-1, What Does It Do, and Where Does It Come From? with Dr. Ben Bikman

In today's episode of The Metabolic Classroom, Dr. Ben Bikman delves into the fascinating topic of GLP-1, a hormone of significant interest in metabolic research. Dr. Bikman sets the stage by expanding the discussion beyond GLP-1 to include other incretions, defining them as a class of hormones produced by the small intestine. These hormones play crucial roles in nutrient metabolism, satiety, and hunger regulation.

The discovery of incretions stemmed from observations following gastric bypass surgeries, where elevated levels of these hormones were found in the bloodstream, leading to improvements in diabetes. Dr. Bikman highlights GLP-1's well-known effect on insulin secretion and glucagon suppression, which contribute to its ability to rapidly correct high glucose levels and improve diabetes. However, he notes the ongoing debate regarding GLP-1's direct insulin secretagogue effect in humans, contrasting findings from cell culture and animal models with recent human studies.

Moving beyond GLP-1, Dr. Bikman discusses other incretions like GIP, PYY, and cholecystokinin, outlining their roles in glucose regulation, appetite control, and digestion. He explores the pharmacological applications of GLP-1 agonists in managing diabetes and obesity, detailing various drugs and their mechanisms of action. Furthermore, he touches upon natural methods to enhance GLP-1 secretion, including dietary factors like protein, fat, and sugars. The session concludes with insights into the live Q&A session, emphasizing the dynamic interaction between science and audience participation in The Metabolic Classroom.

 
#insulin #insulinresistance #type1diabetes #type2diabetes #type2diabetestreatment #type2diabetesawareness #metabolichealth #metabolicsyndrome #metabolicflexibility #metabolicbalance #weightloss #weightlossdiet #weightlossdrugs #fasting #intermittantfasting #insulincontrol #timerestrictedeating #intermitentfasting #intermittentfasting

[LuzGarciaMSNAGNP-C]

Nurse practitioner here doing medical weight loss and primary care. I have become extremely interested in metabolic syndrome and insulin resistance merely because of the high number of people that come in to see me and are pre diabetic or diabetic and have no idea. I have watched many of your videos to get a good understanding. My passion is to help people reverse insulin resistance and get them healthy. Thank you for your videos and wealth of knowledge.

[meatdog]

I am totally immersed in your lectures. Thank you. I practiced family medicine for 50 years, so I'm dialed into education amd enjoy listening.

[zodwangobese]

I am a functional medicine doctor based in South Africa. Thanks for this series, Prof. I learn so much with each one. Yeah, it has forced me to revise my biochemistry, which I often lose sight of in clinical practice. Keep up the good work.

[floatingmoon]

I took the minimum dose of Mounjaro for 5 months. During that time, my blood sugar was excellent, but I saw my thyroid numbers go crazy (have been on Synthroid and Cytomel for years), developed granuloma annulare, and yes, experienced all the gastric and digestive problems. Stopped taking Mounjaro in May 2023. My thyroid function has improved, but not yet quite back where it was previously. The granuloma annulare is almost gone, but the gastric and digestive issues are still not resolved, 9 months later. I will never use any GLP-1 drugs again! I appreciate all your videos and concise information.

[QuasiBlond]

Not only do you have exceptional knowledge, you also have the gift of being a great teacher.

[HealthAtAnyCost]

I will debate the nausea = feeling satiety you mentioned. I have zero nausea and have been on these meds for 2 years (Trulicity, now Mounjaro). My HbA1c has gone from 9.0 to 5.1, all labs that were wildly out of range are now all in range. I am out of the wheelchairs, not using walkers anymore and walking 3+ miles a day. I am also down 220 lbs. (Started at 405 lbs at 5'1" and am now 185 and still falling.) The only side effect I have ever had is slight constipation, easily taken care of with good fiber supps. As another commenter said, the main difference is the shutting up of the constant bullying from my brain to eat and eat and eat until I run out of food, which never filled me up no matter how much. Now, I eat a bit at a time and turn away without any yelling at me to keep going. It's phenomenal how different life was before GLP-1s and now on them. Every single _anything_ has side effects. Weighing the risks and benefits is something we do every single day... from driving to taking a nap. For me, the "possible" risks are far outweighed by the transformation in my life. I'm living and loving it!

[chyla]

Thank you for spending this time to educate us all. Very grateful 🙏🏾💗

[pamelaiverson]

Everyone says it makes your cravings go away because you're nauseous. It's more than that. It makes the food noise in your head go quiet. If you dont have food noise you cant even relate. Its similar to the overall noise on your head go quiet with ADHD medication. ther cravings diminish. Discussion on reddit among Ozempic users include less cravings for cigarettes, alcohol, nail biting, and drug addiction. This isn't because you're full or nauseous! Docs are missing the mark on this. 😢

[NoPronoun]

Thanks for rebroadcasting the live Q&A.

[Snapkrackpop]

These lectures are priceless. Thank you so much for the clear and concise info. It’s come in very handy to help a friend understand better why his metabolic health or rather dysfunction is what it is

[iainneilson]

Спасибо большое, Доктор Бикман! This series is so enlightening and your presentation style is brilliant.

[titasama]

This was fabulous--thank you so much. I'm sharing this with my primary care provider.

[great-garden-watch]

Information you can trust, and because it’s explained on a deeper level than usual, you can see for yourself that it all makes sense. In other words, Dr Bikman backs up his statements with hard science.

[txc]

Mr. Bikman is AOK on nutrition ... He really comes across as a caring person and really into doing quality work in his lab..

[zephomalunga]

I am so grateful to have found you.
I am convinced i am going to probably heal my issues myself by combining your teachings.
I have sleep problems and insulin resistance.

[tennhills]

I have Sjogren's and Hashimoto's. I would like to try low dose GLP-1 for therapy to lower inflammation and metabolic syndrome and calm down the immune system. How do I find a Doctor for this kind of therapy?

[АннаБирюкова-яь]

Your lessons so interesting I can not stop to listen to you!
Best regards from Saint-Petersburg 😊❤

[leandrobecker]

Ben. I am a cardiologist and live in south of Brazil. Here erva mate is quite common. Many people take it every morning with hot water. I would like to know if you could write me the study about glp1. And also the one's regard glp1 tesponse with different fats as we also produce and consume olive oil here.

[monicasarmiento]

Thank you for all your generosity and for sharing your knowledge. It means the world to me and you're the most trastuwordy doctor in my opinion. Thank you sooo much 🤩🤩🤩

[carolr.]

Thank you for all this free vital health information!