Pyrimidine Synthesis

This video explains the synthesis of pyrimidine synthesis from the metabolic intermediates. Pyrimidine biosynthesis involves condensation of CO2 with glutamine and further condensation with aspartate. Pyrimidine synthesis pathway involves some important enzymes carbomylphosphate synthetase II, aspartate transcarbomylase, UMP synthase, thymidylate synthase. Pyrimidine synthesis is one of the high yield topic for usmle.

My other video links related to this topic are as below

Purine synthesis

Regulation of purine synthesis

Regulation of pyrimidine synthesis

Ribonucleotide reductase

Gout

Link for Lesch-Nyhan syndrome

Link for severe combined immunodeficiency disease

I will uploading videos one to two times per week, for regular updates SUBSCRIBE to this channel by clicking the red button below my videos or in the link below:

If you find these videos helpful, spread the news and SHARE with your friends.

For short write up of theory on USMLE Biochemistry and other topics on food and nutrition, obesity, weight loss tips you may visit my site:

checkout other awesome channels to learn biochemistry and other subjects from:

Pictures and video graphics used in my videos came from
which are CC0 creative commons, free for use commercially and no attribution needed.
Some of the pictures are downloaded from
Free to use commercially with no attribution needed.
Appropriate attribution is given to these figures wherever applicable.

Sounds used in my videos mostly came from copyright free sound from

[stargirl]

Whoever watching this don't confuse synthase with synthetase. Synthase enzyme doesn't require energy to form its product but synthetase requires energy.
So it is **ctp synthetase** which convert utp to ctp not **synthase** .

[abubakarsadiqmahmud]

Thanks so much Professor. Your videos help me lot. However, I'm not clear about the pyrimidine metabolism. Please do you have videos on pyrimidine metabolism?

[sitinurfamelia]

Thank you, thank you.. a billion thank for your video.. very understandable and really helpful with my biochemistry subject

[WhyNot-sipj]

00:58 An exception for the cytoplasmic enzymes involved in the De Novo biosynthesis of pyrimidines is the dihydro orotate dehydrogenase (DHORD) ; which is a mitochondrial enzyme !

[eslkmht]

Wow really you are good sir....keep it up sir....

[jagadeeshkumar]

For dna replication process have u put any video sir

[ravinaa]

Informative. But too many ad's. Makes it hard to concentrate