Pyrimidine Synthesis and Salvage Pathway

Lesson on pyrimidine synthesis and metabolism, what it is, medications used to inhibit the pathway and the importance of of the pyrimidine synthesis pathway in human health.

In this lesson, I teach you guys what pyrimidines are, the three pyrimidines (cytosine, uracil, thymine), and an easy way to remember the pyrimidines. I also talk about the critical steps in the pyrimidine synthesis pathway including carbamoyl phosphate synthase 2 (CPS2), orotic acid production, why we need PRPP and the critical importance of thymidylate synthase.

Check out this other channel for more information on biochemistry topics!

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)

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JJ

[drkrunalpatelortho]

Best thing is how highlights clinical points

[edthoreum]

5:30 thymilydate synthases & cancer
9:20 pyrimidine salvage pathway, from cytocine
& thymine(folate?)

[ellengarcia]

Thank you so much. You explained this so clearly. I have to present a paper to my class on cytidine deaminase and the pyrimidine salvage pathway and this video helped a lot.

[davidhansman]

Good lecture, just a note: pyrimidine free bases such as cytosine and thymine are rarely salvaged in humans

[edthoreum]

9:20 pyrimidine salvage pathway, cytoaine

[Nora-dxcy]

WHY GOD WHY DO WE HAVE TO STUDY BIOCHEMISTRY

[katherinecases]

Hello! Just a clarification; isn't the first committed enzyme should be named carbamoyl phosphate synthetase since it uses ATP? based on literature, synthase is an enzyme that doesn't use ATP, so I'm just wondering why you're saying it's synthase when it's using ATP.

Thank you

[ShleepyAlex]

Will it be possible to have a link of the slides of the lecture as well? :)

[SteveSaxony]

is this enough to know about pyrimidine synthesis for usmle step 1? someone who has passed can you telll me/

[oOkramiOo]

What are the end products of dTMP catabolism?

[alevelsdemystified]

is di-hydroorotate the first pyrimidine ring or is it orotic acid?

[Datboigioo]

PRPP is not inhibited by ATP it's inhibited by AMP and GMP

[virtuouswoman]

Y did you start at glutamine and not bicarbonate?

[bharathreddy]

I think the carbamoyl aspartate structure is wrong. because the amino group of aspartate attacks the carbonyl group of carbamoyl phosphate.

[camiyyb]

Orotic acid is a cool substance ... coz it sounds like being erotic acid

[sanyahmaryam]

You know..your lectures are insufficient as all you talk about is how you have mentioned necessary details in other videos. Please tell me how am I supposed to collect information like an old age scholar a day prior to exam. At least do a basic introduction of the stuff. Thank you.