Renal cell carcinoma

Significant improvement in Renal Cell Carcinoma (RCC) treatment was witnessed for the last 5-10 years, which prolonged the survival of RCC patients.
For example, the prognosis of patients with metastatic disease used to ne less than 1 year, but now increased 4 years.
It is due to new molecular targeted therapy and immunotherapy.

[northyland]

I had a radical nephrectomy 3 years ago.. (clear cell 4.7cm) Just passed my 3 year check up. I bike or hike daily. It hasn't slowed me down.

[stanleykim]

KEYNOTE-564 study showed that adjuvant pembrolizumab improved disease-free survival (DFS) compared with placebo after nephrectomy in patients with ccRCC who are at increased risk of recurrence.
Now, the updated report at the 2024 American Society of Clinical Oncology Genitourinary Cancers Symposium showed that it improved overall survival in addition to DFS.

OS benefit was observed across key subgroups, including patients with M0 disease (HR, 0.63; 95% CI, 0.44-0.90) or M1 with no evidence of disease (HR, 0.51; 95% CI, 0.15-1.75), with a PD-L1 combined positive score (CPS) <1 (HR, 0.65; 95% CI, 0.31-1.38) or PD-L1 CPS ≥1 (HR, 0.62; 95% CI, 0.42-0.91), and with presence of sarcomatoid features (HR, 0.69; 95% CI, 0.28-1.70) as well as absence of sarcomatoid features (HR, 0.57; 95% CI, 0.39-0.84).

[maxtaylor]

Thank you doctor for the thorough information much appreciated! I also thank you very much for including the word of God it is always a comfort to live in His truth!

[mkl]

My dad had left radical nephrectomy yesterday. Thank you very much for the detailed presentation.

[stanleykim]

AT 11:38, I said Stage 2 instead of stage 1. Sorry,

[wadeadams]

I have a 4 cm cancer tumor on my right kidney. August 30th 2023 they will. Urology of Virginia will remove the tumor. And save the kidney. Urology of Virginia surgery will be done in Virginia Beach. And I hope I live longer than 5 years after this.

[stanleykim]

At 33:00, I said adjuvant therapy is not indicated because we do not have date proving the benefit of adjuvant therapy after metastasectomy.
However, as I described in the section of adjuvant immunotherapy after nephrectomy, adjuvant immunotherapy x 1 year improved survival (KETNOTE 564: NEJM 2021 Aug. 385:683) in intermediate and poor risk RCC patients. In this trial, they included M1 NED which means completely resected metastatic lesion (mestastasectomy). As such, I believe, adjuvant immunotherapy is indicated after complete metastasectomy.

[RicardoMartinez-oydg]

Dr. God bless you for this video. I am 39 with 1.7cm tumor on North Pole of kidney. Doctors suggest cryoablation or monitoring. Any advice would be greatly appreciated.

[Mary]

Amazing presentation. I hope there will be a video for malignant melanoma.

[hassanghaffari]

my father has 7cm tumor on left kidney and pulmonary nodules with mildly enlarged mediastinal lymph nodes and no symptoms at all doctors have advised cyto reductive nephrectomy for my dad but the tumor is only on the kidney and has not invaded any of nearby organs or lymph nodes not even renal vein or inferior vena cava....is it possible that nodules in lungs are maybe due to some old infection and not due to metastasis? I have seen the films of my dad's ct and the nodules in lungs are smooth and round but the radiologists here in Pakistan are calling it metastatic renal cancer....I have read on internet that malignant nodules in lungs are reply I am really worried and we can't even think of living without our father.

[kk-evvd]

Hi Dr Stanley, my mum is a stage 4 rcc patient, she is on Pazopanib 600mg. But she kept having liver inflammation which caused her to have the pazopanib 600mg dose, on and off. Have you come across a case as such? Would happy to seek for your opinion. Thank you.

[Nusanavee]

Hi Dr, 1 months before I diagnosed with ct scan found my right kidney 4.9 cm rcc, one urology told me he will do robotic surgery but not sure he can save my kidney or not, can you tell me what I should do please, god blessed you.

[RicardoMartinez-oydg]

How much higher is the risk of reoccurrence with cryoablation than surgery?

[adrianjos]

Four -six years should not be considered long term years is long term survival.
Why has there been no studies to locate what causes the kidney to develope cancer ?

[shirleyhuang]

Doc, renal carcinoma, tumor size 4.50cm, can we do radiation treatment? Hope to receive your reply. Advice .

[abhiscreativevideos]

how to treat this disease best treatment refer please

[tugi]

@stanleykim1924 could you share your references?