T4 Phage attacking E.coli

The WHO estimates up to 700,000 patients died in of multidrug resistant bacterial infections globally in 2016. This rise of multidrug resistant (MDR) bacteria is mainly driven by the excessive use of antibiotics in meat production. Some estimates claim 80% of antibiotics produced globally are used on poultry and pigs. The health threat posed by MDR infections prompted researchers to explore phage therapy again. Several publications have recently reported spectacular successes in the fight against MDR bacterial infections in humans but also livestock. While in the past phage therapy was shunned by pharma companies for various challenges (see below), now the commercial potential and advances in genetics have enticed biotech companies to exploit the deadly potential of phagetherapy as a secret weapon to kill superbugs.

Please subscribe to our channel, if you like this content to show your support for our work. Thank you!

Now about the amazing nanoworld of bacteriophages:
More than 100 years ago the Franco-Canadian scientist Felix d’Herelle identified bacteriophages! They look like spaceships from another world and are most fearsome killing machines, fortunately they are targeting exclusively bacteria. D’Herelle and his colleague George Eliava immediately realised phages could be weaponised to help patients to fight off bacterial infections. However, in the western hemisphere the control of life-threatening bacterial infections was soon achieved with antibiotics, while phages and viruses became favourite research tools of geneticists. This explains why the bacteriophage T4, which is depicted here, is one of the most intensely studied biological objects. However, phage therapy was pioneered by the Eliava Institute in Georgia, where it has been advanced ever since its discovery.

Phages stick to bacteria with their leg-like fibres, which triggers a change in the protein conformation ramming their shaft into the bacterial hull. The interior of the shaft contains a needle, which punctures the bacterial envelope enabling the phage to inject its genetic material. The phage genome within minutes overcomes the bacterial defences, phage components are assembled within the cell before it ruptures to release a new wave of phages. Several biotech companies are now ready to exploit the deadly potential of phage therapy as a secret weapon to kill superbugs.
Phage therapy frequently relies on extensive phage collections.

Please feel free to use our images and videos for non-commercial purposes like #teaching, or get in touch if you are interested in scientifically accurate #animation of high quality. We appreciate if you follow our channel for more of our animations.

Music by: Ross Bugden - Last Dawn (Copyright and Royalty Free)

This video was produced by biolution GmbH and can be shared freely without changes for non-commercial purposes.
#DNA #bacteriophage #research #science #technology #teaching

References:
Specific and Selective Bacteriophages in the Fight against Multidrug-resistant Acinetobacter baumannii. Bagińska N, et al. Virol Sin. 15. doi: 10.1007/s12250-019-00125-0.
Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient. Law N, et al., Infection. 2019 May 17. doi: 10.1007/s15010-019-01319-0.
Synergistic effect of phage therapy using a cocktail rather than a single phage in the control of severe colibacillosis in quails. Naghizadeh M et al., Poult Sci. 2019 Feb 1;98(2):653-663. doi: 10.3382/ps/pey414.

[xx_admiralhipper_xx]

Even mother nature got her own nanomachines

[jamesjesus]

Props to the cameraman for recording this so well.

[LCRequiem]

This virus is like a robot spider that attacks a bacteria and injects their properties

[alainm]

I took an immunology class post graduate, the things I learned blew my mind. Great professor too, the way she described things, often compared the immune system to a gun

[kilroy]

It's nice to know something so scary looking actually serves our lives.

[AAvfx]

I'm fascinated by these animations! 🤯

[silent]

Super adapted bacteria: You can't defeat me

Immune system: Oh, I know! But, they can

Virus:

[nixosgoddess]

can we just take a moment to appreciate that even tho this was made like 2 years ago, biolution still hearts and replys to comments

[DreamscapeSYN]

I didn’t know that bacteria could be so... FLOOFY!!!

[mexify_void]

Bacteria: HAHAHHAHAAHAHAHHA NO ONE CAN DEFEAT ME!!!

Antibiotics: Prepare for trouble
Bacteriophage: And make it double

[nopushbutton]

I like the depiction of E. coli. It's so shaggy

[kytsuro]

Welcome once again to the unknown part of YouTube, the algorithm brought us here.
The Power of YouTube Is with us

[sultansakr]

If you're pissed off, just remember that these are attacking for you

[mottmann]

T4 phage: Zippity boppity, this bacterium is now my property

[riotbreaker]

When you realize that E. Coli has predators

[Anonymous-pcqr]

My teacher just taught experiment by Harshey and Chase for the search of genetic material and today only I got this video as a suggestion
What a coincidence 💗
Btw loved the animation
Thanks for uploading 💗

[WhisperedSynthsASMR]

Beautiful animation. Cute little phages 👾

[biolution]

If you like this content we would ask you politely for a little favour. Please subscribe to our channel, share it with your friends to show your support for our work. We are also grateful for any comment, may it be appreciative or constructive criticsm to improve in the future. We try to answer any queries within a day. Some of you have even included this vid in their playlists, which is also very helpful to increase our exposure. Thank you!

[jivvr]

Fun fact: a type of bacteriophage can only affect 1 bacterium species, in this case, A t4 phage for e.coli

[davidcopperfield]

imagine being part of a war without knowing it...
imagine being a battlefield yourself...
-.-