Tryptophan operon

Tryptophan operon, commonly known as trp operon is regulated at two levels. One is by the trp repressor that inhibits transcription of trp genes when the concentration of tryptophan is high and other is by the leader sequence that forms a termination loop to halt RNA polymerase, causing transcription attenuation.

[XY-ygci]

The clearest video about trp regulation. Thank you sir

[akwamann]

i just want to tell you that you explain these topics A LOT better than my professors. You make it very easy to follow and understand so thank you very much!

[rokhiya]

Clean, clear-cut, informative, Thank you sir

[debishabiswas]

You are the best explainer at tryptophan operon I have ever seen

[bobboo]

so basically when trp is low the ribosome is waiting for more trp to come... the wait causes 2 and 3 to form a weak loop and this prevents the strong hair pin between sequence 3 and 4 so no termination occurs.

[bts_rollercosterlifepurplearmy]

Seriously you solve my every confusions about the topics....
Thanks 👍👍👍

[anjaliagarwal]

Your videos about these concepts are the best!!!
Short, concise, to the point and easy to understand. Thank you so much for these videos. I hope you'll continue these for every topic if possible. Thank you again.😊😊

[srishtichakraborty]

This is the best video I've seen on Trp operon.

[GoldenMoon-bbnw]

The trp used by the ribosomes ... that's why they were slowing down when the trp is low .. that's make so much sense thanks professor!!!

[busrahacoglu]

Thank you, it feels great to understand it clearly and quickly. 🤩☺☺

[polar]

This is very easy to understand!! Thank youuuu

[eryk]

How exactly does the loop structure "unbinds" the RNA polymerase? I cannot imagine how this structure interrupts the transcription. You mentioned weak A-U bonds, which break easily. But they are also present when the loop structure is formed between Seq2 and Seq3.

But overall: great video, I now understand (most) of the trp-Operon (:

[erminakirstainefernandez]

Thanks bro....please do a video on histidine operon❤

[pallobbarai]

Thank you so much. It's help me a lot.😃😁🤩

[bhavikachhablani]

Very nice explanation thankyou so much

[nibrasulhaque]

What happen to poly U region when sequence 4 remains free? How can we say that it will continue the process of transcription while U region is exposed??

[nirojbanik]

Thank you for making it so easy to understand ☺️

[lennartantz]

So after the Formation of enough Trp, the transcription termination loop halts the Polymerase.
But what about the repressor? Is the repressor just active at higher concentrations or does it work simultaneously?
By the way, briliant video!