Lymphoma Explained Clearly - Hodgkins & Non-Hodgkin's Pathophysiology

This is video 1 of 2 on lymphoma.

Speaker: Roger Seheult, MD
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

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Recommended Audience: Health care professionals and medical students: including physicians, nurse practitioners, physician assistants, nurses, respiratory therapists, EMT and paramedics, and many others. Review for USMLE, MCAT, PANCE, NCLEX, NAPLEX, NDBE, RN, RT, MD, DO, PA, NP school and board examinations.

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Produced by Kyle Allred PA-C

Please note: MedCram medical videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your health care provider.

[meong]

I was diagnosed with Hodgin Lymphoma since last month, now im getting chemotherapy. Pray for me, i hope luck is in my side so I can be Cured

[racheltumey]

I'm not studying to be a doctor/nurse or anything. but my daughter was just diagnosed with lymphoma and this is the most informative video I have seen. Thank you!

[roselucht]

I’ve been diagnosed with Invasive lobular breast cancer and through the CAT scan and a biopsy they found I have B cell Non Hodgkin’s Lymphoma.
I had a bone marrow biopsy and I’m awaiting results in 5 days, when I see my Oncologist. The net day I will be having my bilateral mastectomy. All this waiting (6 months of all this ) is really hard

[alisonmorgan]

Diagnosed in May of 2021 with diffuse lg B Cell non Hodgkin's lymphoma. Started aggressive chemo immediately, May -dec of 2021. Shrunk the tumor, but my body has not been the same. I lost 110 pounds, constant fatigue, have had COVID 4 times, spent Jan of 2022 in the hospital fighting COVID and pneumonia, while just coming off chemo, my face has aged at least 10 year's. If I get a recurrent diagnosis, I'll think twice about chemo.

[tgtina.g]

Last night I noticed my right side under my arm to the front is swollen, were the lymph nodes are. Just one side very visibly. I don't feel a lump underneath but I didn't palpate to much because it makes me feel uncomfortable. I made a doctor appointment and it's in 8 days.. my biological sister has had breast cancer twice and 3 of my paternal aunts have had breast cancer. My mother who is in her 70s never had cancer but her along with my sister and paternal aunts test positive for braket. I never got tested because my insurance would not cover. The spit sample they took on me was sent for testing but I recieved a letter saying they couldn't test. But anyways.. I have a doc appointment soon and I'm hoping I don't have cancer .I would hope whoever is reading this can say a prayer for me. I'm 46 years old and my name is Tina.

[tonnikask]

i have seen many lectures meant for medical students but they are not as full of information as this one...this is really great :) this lecture was worth spending time...moving on to next lecture with high hopes 

[bfoster]

All I know is I had diffused large B cell non Hoskins lymphoma. I finished my chemo Jan18, 2018. Feel great. It was found when I got my mammogram. Lady's get your mammogram every year.

[qnrbcuw]

Good day thanks for coming back to me to hear you. Such a wonderful voice and way to make me understand everything even english is not my mother language. Bless you.

[ned]

Dude i love your channel.Every time im stuck  in first aid I always wind up at your videos.

[amandalal]

Just add that, bcl2 is antiapoptotic gene that gets overexpressed when translocated next to IgH gene (on Chr 14), so cells skip apoptosis, hence lymphoma.

[harch]

I was taught that Bcl-2 allowed the cell to avoid apoptosis, and the translocation junctions the Bcl-2 gene to the gene encoding the heavy chain of immunoglobulins. B cells transcribe the immunoglobulin genes a lot, so every time the heavy chain gene was being transcribed, the Bcl-2 gene would be transcribed too, giving the cell more Bcl-2 and therefore more evasion of apoptosis...and I just realised someone else has already explained this further down but oh well :p nice video though! thanks!

[ISinisterI]

You made a mistake while explaining follicular lymphoma t(14;18). bcl-2 is an ANTI-apoptotic gene that codes for stabilization of the mitochondrial membrane preventing cytochrome c loss from the inner mitochondrial space (and downstream caspase cascade). The translocation to the heavy chain locus on chromosome 14 results in overexpression of bcl-2 making the cells unresponsive to apoptosis.

[Hamigal]

I just got a NHL diagnosis 2 days ago. I see the Oncologist/Hematologist Aug 10.

[jimkhatib]

In January I was diagnosed with T cell anaplastic large cell lymphoma, ALK positive. Truly fascinating stuff I’ve learned throughout this.

[vmjable]

thanks for the video :). one thing i wanted to mention... i assumed that the translocation(14:18) of the bcl2 gene to the Ig heavy chain locus caused overexpression of bcl2 which stabalized the mitochondria and prevented apoptosis...rendering the cell immortal...

[azinrostami]

Hello, that was great, please more lectures about chemotherapy and cancer

[imagonzalez]

I’ve been treating for non-Hodgkins lymphoma and before my last treatment I was diagnosed with classic Hodgkin lymphoma I my lung. How could this happen.?

[Bekind]

Not a comment, I'm just putting this here for reference as I read this video. I got tired of pausing and going into my iBooks to see lab work. Remove if you want. Thank you.
Large B cell lymphoma. Large atypical cells positive for cd20, pax5, significant patchy staining for bcl-6. The large cells are negative for ae1/ae3 cd3, c5, cd10, and cyclin d1. Small background lymphocytes show populations that are both cd20 and pax5 positive as well as a population that is cd3 cd5positive. Positive staining for bcl6 may indicate lymphoma of center cell origin.

[MoamerKday]

first time to understand lymphoma, Thanks Dr

[ISANDRA]

great!! can you please do one on Diabetes??? thank you