Pig plasma to live longer?

Hello, i am back! Blood, sweat and tears have been shed these past months of absence. But enough sweating was done during the summer, tears have already been shed, so that just leaves me with blood. And whether taking a part of blood (plasma) and injecting it into old animals is enough for rejuvenation. That’s right, many of you may remember, earlier this year i made a video on the oldest living rat.- and now we have some updates: in particular, (i) what actually were the rats given, and (ii) what changes were seen, showing both some DNAm and glycan age data.

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TIMESTAMPS:
Intro and recap - 00:00
New results - 02:45
What were the rats given? - 05:05

References:
I took clips of an interview with Dr Harold Katcher from @ModernHealthspan 's channel

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

[SkyRiver]

Good to see someone besides modern healthspan is covering this. I have been waiting years for further info about this.

[hankfowler]

I love the accent and intellect in your voice.

[xXjuanpabloXx]

I'm currently pursuing a mastery's degree. Having recently come out of college, I wanted to thank you for your videos. They have brought me a lot of insight into the world of science and how to interpret these results and graphs, particularly in the aging field of study which is what I'd like to do for a living.

But also, for informing people about all these recent discoveries which are very exciting, keep doing what you do :)

[peterz]

Glad you're back! Missed the quality of your vides. So, as you know, since 2005 the Conboys have moved on to focusing on old plasma (2020 and 2022 papers) as a major contributor to aging and shown that removal of a large fraction of plasma is rejuvenating, although for how long is not known. I'm wondering, with EVs being discussed, if one mechanism of plasma replacement is the accelerated turnover of EVs. Plasma replacement does show increased expression of youthful genes. Plasma replacement has the advantage of being free to do on smaller scale at local blood bank and can be done instead of normal whole blood donation (25% plasma volume per donation).

[ArticBlueFox]

Hopefully this will lead to new areas of research, and eventually practical methods for improving human health, youth, and longevity. I am glad that you are still here keeping us up to date on new research, and this video is great as always.

[brianfjlynch]

You are a wonderful contributor and communicator. I and the community really enjoy your clear precise and helpful videos. Thank you.

[mkvalor]

Welcome back, Eleanor! We kept the light on for ya. 🙂

[kingsize]

Great to see my favorite science reporter back in the grind again.

[williamwalker]

Amazing how the "real media" never covers anything this important. Guess I should contribute to the Patreon here ;)

[alexz]

Good to see you are making more videos, I love how dense they are, sometimes it takes me a few watches to fully understand everything you're saying. I run BOINC to contribute to health research and would love to see you talk about the results of a BOINC project one day. None are currently focused on longevity, but there are a number of health research ones like World Community Grid (mostly cancer) and SiDock (covid).

[hankfowler]

I've wondered if you could get a young person to donate blood of the same type and infuse the plasma for youthful benefits. This suggests that might be possible with piglet blood. I love you accent and you explain biochemistry so well. I had to memorize Kreb's cycle in one of my biochem classes. Have forgotten it since.

[TheEngadine]

Glad to see you back again. But my question is about how can be peer reviewed a study like Katcher's having E5 - its core compound with their effect on aging supossed to be replicated by peers - under the secrecy of a patent?.

[SkyRiver]

I hope Harold is successful in this. Not just for the good of humanity, but because major pharmaceutical companies have spent hundreds of millions of dollars attempting to do this without success.

[elon]

Are you going to make another video on this? So yeah basically they isolated exosomes from pig plasma. Though just so you know exosomes are usually typically collected from mesenchymal stem cells.

[mishayeliseev]

Thank you for your breakdown! It is a very encouraging development. Are there techniques to sequence the mRNAs in ecms?

[pietercastelein]

There are medicines on the market with a pig brain derived neurotrophic growth factors, called Cerebrolysin. I wonder if you also could increase the absorption of these peptides when you encapsulate those with a PEG molecule.

[deanrobinson]

Oh! E5, E xtracelluar V esicles (V for 5)

[anthonymason]

Great to see Dr Harold's work being talked about. I think its the most promising work in this field by a country mile.
Why not try get an interview with the good Doctor Himself? He is on linked in. A very agreeable guy. I'm sure he would enjoy discussing his work with you.

[ChessMasterNate]

This therapy would likely be very expensive if derived from plasma donors. And synthesizing it is probably beyond our current technology.
I guess this should not be a surprise.

What I'd like to see is if injections of albumin can extend life. Recently, a higher level was shown to be an indicator of survival in extreme longevity when studying mostly centenarians. Albumin is a lot easier, and cheaper, to make. If we kept it at youthful levels in mice, well, I would like to see what would happen.

[GeoffryGifari]

Is there anything in particular why pigs are selected?
I also read about pig tissue used in lab-grown organ studies... seems like regeneration research often involves pigs