Paediatric and adult high grade gliomas: A tale of a histone tail

Dr Nada Jabado speaks with ecancertv at AACR 2016 about epigenetic mutations found in high grade gliomas.

Single nucleotide polymorphisms that occur within the epigenome can alter the structural assembly of proteins and the function of cellular components, with Dr Jabado reporting on a handful of mutations that can alter cell architecture, resulting in a pluripotent and resistant cancer.

She also describes the incidence of ependymoma, apparently not characterised by mutational origin, but a structural malformation that results in high mortality.