How do Bile Acid Sequestrants Work? (+ Pharmacology)

How do bile acid sequestrants work?

Bile acid sequestrants are used to treat hypercholesterolemia or high LDL levels. Anti-hyperlipidemia therapy seeks to prevent the complications heart attack, stroke and other ASCVD risks.

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Answers:
1.)B
2.)C
3.)D
4.)A

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This pharmacology lecture covers topics such as dyslipidemia drugs. We talk about Bile acid sequestrants and how they block the reabsorbtion of bile, causing the liver to make more bile thus lowering LDL levels. Also we talk about the pathophysiology of LDL cholesterol, regulation of LDL, HDL, LDL and other complications of bad cholesterol buildup. We discuss the mechanism of action of BAS and their side effects. Drugs mentioned include; cholestyramine, Questran, colestipol, Colestid, colesevelam, Welchol.

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[DrugChug]

Hopefully this video helps some of you!
Consider subscribing for more videos!

[andreabroder]

Thank you for this video. I was misdiagnised with IBS 15 years ago as I had my gallbladder removed and was experiencing IBS -D. I could not leave the house without running to the bathroom or feeling pain every time I ate. As a result I have developed panic attacks and agoraphobia due to the fear of having accidents in public. It has affected my marriage, my childs life, my working abilities and lead to major depression. I am now taking a Bile Sequestrant and it has changed my life. I only wish that the doctor who removed my gallbladder informed me of BAM so I did not waste 15 years of my life in terrifying fear. I now have to spend time on the emotional and mental scar of leaving the house but I am hoping I can gain the confidence back knowing my internal system can function properly. Thank God for Science, Research and Doctors.

[FacebyEfti]

I gotta tell you.. You're an amazing teacher!

[angiemartin]

I truly wish that you were continuing to make videos. The knowledge that I am gaining and understanding for pharmacology for nursing school has come through your videos. Being an auditory and visual learner can be hard in nursing school. Reading and pictures in a book do nothing for my brain. Your videos have help so much and correlate with my way of processing information. It brings the information to life! Thank you for the videos that you have done!!! Hope that we will have more videos in the future!

[meganb]

The rationales for side effects were especially helpful. Great video!

[kgfflores-gomez]

Thank you for making this fun, walking me through the process and the pop quiz at the end. Reminds me of class which is nostalgic. Thank you!

[lovelifeandcrafts]

Great video. I have had bowel issues since birth which has progressively got worse in the past 7 years. I have tried every IBS diet and medication there is : none worked. All my tests at the gp always come back normal. I am only now being referred gastro at the age of 27. I eat a balanced diet and exersice as much as i can (disabled). It does not matter what i eat or drink, healthy or unhealthy. They are now finally looking to see if i have BAM or IBD.

Symptoms:
Loose stools or diarrhoea (3-6+ or even upto 12+ when ill)
Yellow ish when i wipe.
Acidic or eggy smell.
Can't digest certain foods like sweetcorn.
Daily nausea.
Fatigue.
Bad days, i get chills, shakes, vertigo and feel like throwing up.
Lower abdominal pain.
Weight gain NOT weight loss.

It's tough as the NHS in the UK is so behind in so many areas hence why it's taken so long to get help.

I have been started of colestyramine to trial and see if they work. I am on day 3 and still no change. Waiting on sehcat scan and results from bloods & stool.

Thanks for the video. Xx

[karlakozak]

Life saver and you're to the the point with photos. Excellent job!

[sooshaa]

Thank you so much ...I'm currently taking pharmacology in NP school and this helped me understand the concept.

[jessreed]

How can we absorb those vitamins if we are taking cholestyramine?

[milliemee]

Great great explanation. Can you think about doing more lesions for ICU and ER nurses. Please

[prncssortiz]

Omg you totally nailed it. Perfect video explanation(visual aid) for pple who need to see pictures and words together. My cousin just received the powder form today and I decided to do some research on. Your video🎥 perfectly explained the product. Thank you for your creativity!😊🙏

[navinroonwal]

I think m going to become doctor without degree just by watching your videos ✌️✌️ i can debate with doctors.. Great content brother keep growing we need more videos ✌️

[humishah]

OmG i never comment but that was brilliant explanation thank u so much!!!

[rolaa.k]

I want to ask a question what happen to this whole process of breaking fats when the gallbladder is removed how does the body tend to work normal after the removal ???

[mikepetroff]

Bile is essential and not in sufficient levels with many people. Incidentally high LDL appears to be highly over-rated.

[erickaarmstrong]

Can you do this same video on how this works when you gallbladder is removed. Also if you have a right lobe liver resection.

[billyc]

Great video...as a sufferer of BAM these drugs have help me tremendously and as a bonus, lowers my cholesterol Win/Win

[goldwingman]

I have been using this Med for 38 years .

[MsPerfectRed]

So this is why I’ve had diarrhea for the past 5+ years ever since I had my gall bladder removed. My gall bladder isn’t there to regulate the bile acid and my liver is just pushing it out. So esp when I eat anything fatty it makes it worse. My body can’t handle all the oil.