Bile Acid Synthesis | Classic and Alternative Pathways | Primary and Secondary Bile Acids

Lesson on Bile Acid Synthesis Pathway: Classic and Alternative Pathways, Primary and Secondary Bile Acids and Bile Salts. Bile acids are produced from cholesterol in the liver. Primary bile acids are produced via the classic and alternative bile acid synthesis pathways. Primary bile acids can also be conjugated to amino acids like glycine and taurine, which aids in bile acids ability to emulsify fats. Furthermore, primary bile acids can be processed by bacterial enzymes to form secondary bile acids.

Hey everyone. In this lesson, you will learn about bile acid synthesis via the classic and alternative pathways. You will also learn the chemical structural modifications of cholesterol that occur to produce a primary bile acid. Furthermore, you will also learn the differences between primary and secondary bile acids, and bile salts and why it is important that we conjugate amino acids to bile acids during synthesis.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

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[sammy]

This is the best description of Bile acids by far on youtube. Keep up the good work. Thank you

[surenderkaswan]

Thanks a lot ! Correction for bacterial 7 alpha dehydroxylase rather than hydroxylase

[zannatul]

Very helpful sir, thank you so much🙏🏻

[sadeghriazi]

Vitamin c deficiency can cause bile salts deficiency????

[nh]

the secondary bile acids, do they form inside the gallbladder? Or in duodenum?

[persistentone]

Can you point us to the video on enterohepatic circulation?

[feelchemistry]

Thank you sir.. But I have a question please why hydroxile group attached to 3 7 and 12 carbon? Why not to others carbon.. And also why bacteria act their what they got from here please help

[IndiaFirst-WC]

What's the fate of these Deoxycholic acid & Lithocholic acid?

[vikrantgoswami]

Thanks . Very helpfull :)
Sir any video on cholesterol structure ?

[AmanitaWoodrose]

Would be v interested to know if statins affect this process if anyone has any info?

[fernandasiordia]

Shouldn't the bacteria have 7 alpha dehydroxylase not hydroxylate?

[imanimad]

Why if the bile acid is increased, it will happen cholelithiasis?

[metipallearuna]

Bile acid accumulation can lead to stony liver

[ezracheney]

ilustrate mitochondria in a separate graph for the alternative pathway; and the bile acid is for FXR and G-protein signal trnsduction--the four points you illustrate for the Purpose lacking insight-and the p450 enzymatic reactions need be detailed of how they act on the hydroylaation steps,