Protein Structure Prediction using Artificial Intilligence by AlphaFold2

This Tutorial will help you in predicting the structure of your protein very easily by ALPHAFOLD2. Computational prediction of protein structures, which has been a long-standing challenge in molecular biology for more than 40 years, may be able to fill this gap. Many useful and accurate three-dimensional models have been computed from amino acid sequences by using the Artificial Intelligence to find out the way in which amino acids fold the protein into 3D structure. AlphaFold is an AI system developed by DeepMind that predicts a protein’s 3D structure from its amino acid sequence. It regularly achieves accuracy competitive with experiment. Underpinning the latest version of AlphaFold is a novel machine learning approach that incorporates physical and biological knowledge about protein structure, leveraging multi-sequence alignments, into the design of the deep learning algorithm.

Alphafold Colab

[FOODIESWITHAQSA]

Informative one..we need this kind of cooperation from our seniors to increase the level of our education system😍

[syedrizwanshah]

Very Informative & understandable one.

[sayanchakraborty]

Sir can you tell me how to dock protein protein and peptide

[hosnearaakter]

Can you please share the link of the next video where you elaborately explained alphafold 2 with example

[sanamirza]

Sir can u please mention the name of protein similarity check software

[muslehasvlogs]

Hi sir, after prediction, I got JSON file and CIF file. Would you kindly inform how to convert this file as pdb format? Thank you.

[Roshu-lh]

Can it also predict unknown protein having more then one subunit.

[parisaas]

Thank you so much, I really enjoy it.

[nopainnogain.sylvere]

very informative. I predicted 3D protein structure using Phyre2, then got a model with 99% confidence, and 18 % coverage. 58 % of residues are disordered. May I use this protein for docking analysis?

[fatiullah]

Thanks a lot for such an informative lecture.

[hasnainjadoon]

Sir that's amazing pls can we do that on laptop CPU system?

[ammarkhazal]

Very useful Dr, if can Dr make video regarding to the analysis of protein structure

[hitkarsh]

Sir, Can we do MD simulation of a protein for which the crystal structure are not available??

[mriganka]

Thanks. After predicted via Alphafold2colab, then is it recommended to go refinement of that model structure?

[RavindraThakkar]

I have two peptides with 17 residues each, one is head to tail cyclic peptide and the other is stapled peptide. Does alphafold2 work with chemically modified peptides?

[Em_Z]

Thank you very much for sharing.. I have question sir, My protein sequence is 4363 aa, Is there any way to fold my sequence with alphafold?

[Rekhabohra]

Informative one. thank you so much. If protein has Intrinsically disorder regions, which Software I can use in order to predict the structure and MD simulation?

[VIPASHAABROL]

sir i want guidance regarding my research work on protein prediction how can i contact you

[juniorkidscorner]

Sir can we do just protein structure prediction as thesis for project?

[akanshapandit]

Sir nice video.. Its just amazing.. I have a request, can you please make some videos on how to calculate PMF (Potential of Mean force) for steered MD simulations (SMD) using Jarzynski equality...