What Is AlphaFold? | NEJM

[michaelmuchow]

When I was a postdoc many years ago, we had a patient who was missing an exon in a tumor suppressor gene that coded for the domain that interacted with a kinase to regulate it. My PI asked if I could translate the mRNA sequence into amino acids and then "use some software tool" to get the 3D structure for the protein. I said, "Um, that doesn't exist and if it did, we would need a supercomputer to run it." The best I could do was highlight the deletion using an existing crystal structure to show what was missing.

[mattcool]

I feel like I'm kind of a smart person. I feel like I kind of understand protein folding. I feel like I kind of understand AI. That was completely Greek to me.

[cansabanci]

Similar problem to turbulent flow. You can experiment to find it but simulation is definitely faster and cheaper, so it's also needed at least for preliminary understanding

[Zulu]

There are gaps in this explanation of the structure.

[jgonsalk]

So, if I'm understanding this correctly, the pairwise relationships are intercorrelated within a hyperspace in a multi-dimensional system and is then reduced to a scalar across seven delirious elves who wrote the last seasons of Game of Thrones?

[albrigo]

Even if I am a scientist, you have badly explained how it works, you should consider that a YT channel is not a scientific conference between pairs.

[jaimecarrillo]

Ok so all this for what? Again please!