The Challenges of Evidence-Based Medicine (Part 1)

In this grand rounds lecture John P.A. Ioannidis, MD, DSc, evaluates various levels of evidence and explores the importance of quality, significance, reproducibility, and feasibility. He also explains the complexities related to nutrition and lifestyle research and lays the foundation for responsibly establishing the evidence in this area. Dr. Ioannidis is a Professor of Medicine, of Epidemiology and Population Health, and (by courtesy) of Biomedical Data Science, and of Statistics and Co-Director, Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA.

Hosted by Mark Hyman, MD, Head of Strategy and Innovation, Cleveland Clinic, Center for Functional Medicine

[YDwelve]

It almost feels shameful to call him an "expert" because of how disgraced that term has become. Thank you John P.A. Ioannidis, MD, DSc for being one of the few people that kept the credibility of the sciences alive.

[jeffreymagedanz]

Some argue that we shouldn't emphasize the flaws in science, because it will give ammunition to those who are "anti-science." However, overconfidence is a large part of what creates distrust. If scientists do more to acknowledge their biases and show that those biases are being addressed, there will be less distrust.

[rawgaw]

This man needs to be heard far and wide.

[sebacatana]

It's so funny how he talks about evidence based medicine and the first slide has the logo of the Institute for Functional Medicine 🤣 John is a hero.

[fdm]

The world doesn't need saving by medicine it needs saving from medicine

[allanforce]

So which trial data do you think they would share for which trials...they know the data will be looked at closely...I wonder if the other 54 percent produces similar results

[chaz]

I'd rather be treated by a doctor with 30 years of clinical experience using his expertise, judgement, and intuition than a by-the-book doctor following the latest "evidence based" guidelines.

The former is a genuine professional. The latter is a technician/McDoctor at best, and a state licensed drug pusher for Big Pharma at worst.

[dannyjensen]

In this eara of covid19 induced insanity a talk by John Ioannidis feels like gourmet feast after 2 months of eating porridge...please come to denmark and save us from our homegrown "experts" in EBM...

[caroledempsey]

Will you be getting the COVID vaccine ?

[chazlon]

Does anybody know what type of diet he recommends??

[hareriti]

The US has approx. 30k to max 60k influenza related deaths/a, the US surpassed 350k corona related deaths by now, does that mean the arguement, that covid19 shows similar mortality rates as the flu still count???

[jaymac]

WOW, I listened to you for a couple of lost me at the end when you pushed vaccines and climate change.

[anonymousAJ]

I think it would be better to talk about years of longevity reduced by smoking rather than smoking is going to kill so many people. I promise you, those people will eventually die anyway.