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Primary Hemostasis - Platelet Plug & Blood Clot- Mnemonic
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Secondary hemostasis, on the other hand, deals with converting fibrinogen into fibrin via the coagulation cascade to form a strong plug to stop bleeding.
Too little coagulation and you'll bleed. Too much coagulation and you will thrombose. Both extremes are bad.
Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).
Platelets are called thrombocytes "cells of thrombus".
The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.
When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).
After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
Books that I use for this series:
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Platelet Plug - Primary Hemostasis - How The Clot Forms!
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Primary Hemostasis: Platelet Plug Formation [Step-by-Step Animation]
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Platelet Plug Formation - Mechanisms
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Primary Hemostasis - Part 1: Platelet Adhesion
0:04:45
Primary Hemostasis - Platelet Plug & Blood Clot- Mnemonic
0:10:51
Primary hemostasis | Advanced hematologic system physiology | Health & Medicine | Khan Academy
0:17:47
Hemostasis: Lesson 2 - Platelet Activation and Aggregation
0:10:00
Hemostasis
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Platelet Activation and Factors for Clot Formation
0:43:13
Hematology | Hemostasis: Coagulation Cascade
0:12:54
Hemostasis: Lesson 1 - An Introduction
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Platelet Plug Formation is SO AMAZING
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🥧 🥕 WHILE I COOK | Platelet Plug | Primary Hemostasis | Basic Hematologic Physiology Animation
0:08:08
Primary Hemostasis - Part 2: Platelet Activation
0:04:38
Blood Clotting (Hemostasis)
0:02:30
Coagulation Cascade Animation - Physiology of Hemostasis
0:03:30
Primary Hemostasis: FUN and SIMPLE!
0:05:49
Hemostasis | Vasoconstriction | Platelets Plug Formation | Coagulation
0:07:17
Platelet Plug Formation | Platelet Mediated Hemostasis
0:09:58
Coagulation Cascade and Fibrinolysis - clotting factors, regulation and control mechanism
0:03:46
1. Primary hemostasis
0:12:01
Primary Hemostasis Physiology of Platelets Adhesion and Aggregation | V-Learning™
0:06:25
Hemostasis | Advanced hematologic system physiology | Health & Medicine | Khan Academy
0:08:46
Hemostasis - How your blood clots - Overview
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