Platelet Plug - Primary Hemostasis - Platelet Adhesion & Aggregation - How The Clot Forms!

Platelet Plug - Primary Hemostasis - Platelet Adhesion & Aggregation - How The Clot Forms!

Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).

Platelets are called thrombocytes "cells of thrombus".

The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.

When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).

After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.

Hemostasis is defined as “cessation of blood bleeding”.

There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).

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Books that I use for this series:

[MedicosisPerfectionalis]

💊 Cardiac Pharmacology Lectures:

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[Olive]

hello a question here: image under 5:51, PDGF and ADP are found in cytoplasm, so why is there a repeat under image 6:12 the platelet granules which also has PDGF and ADP?