The X and Y Chromosomes DON'T Determine Your Sex

In this video we explore two examples of disorders of sexual development. Swyer Syndrome: XY Female
Le Chapelle Syndrome: XX Male

⚠️Disclaimer:
I am giving this information to you as a medical student who is interested in women’s health, sexual health, fertility and pregnancies. I am not a qualified doctor. I research topics out of my own self interest. If you are worried or concerned, always seek advice from your GP. This video is not for diagnostic purposes but for information only.

[aeomaster]

Very well done. A clearly laid out explanation of how male / female genetic instructions can get mixed up with mixed results.

[ariabey]

This is the first video of yours that I came across, and I absolutely love your channel!!! I'm a person born with "46, XX and 46, XY Chimerism". I have a penis, so I was considered male at birth. I never felt as relatable to being raised as a boy or man in the social-typical situation of such circumstance.

Once I hit puberty, I grew a beard and my voice got deeper, but I also grew typical female features (the curvature, breasts, hips, butt, etc) and started to have what my doctor calls "ghost menstrual cycles" where I have the typical symptoms of a menstrual cycle each month, but without the vagina present. As a child who was being raised as a man, I got really confused and worked to hide my female features until I finally came out as transgender in 2018. It was right after that I found out about my condition. I never took hormone therapy; I simply stopped trying to hide my natural body, and I look totally different now than what I did 6 years ago.

I don't have Swyer syndrome, but I did learn so much more than I expected to. Thank you for educating the world about human psycho-chemical-anatomy!!!!

[mysticg]

I"m in the medical field and the information you provided is misleading. Yes, chromosomes in 99.9% of the human population determines the biological sex of binary male or female . Why? Because the chromosome such as Y carries the genes specifically SRY male gene, which determines male sex development. Female development occurs when there is no Y present, and this only changes if there is an intersex condition.

De La Chapelle syndrome XX males 80% will develop fully as male, this intersex condition is caused by the SRY gene becoming translocated on one of the XX chromosomes which means their XX chromosomes are not true female chromosomes. Why? because true XX female chromosomes don't have a SRY male gene on the X chromosomes. 

In Swyer syndrome or XY female. Their chromosomes are not true male chromosomes because the SRY male gene which is responsible for male development is either missing or mutated resulting in them developmentally primarily as female. They will have a vagina, fallopian tubes, uterus but gonads (ovaries, testes) are not functional due to being not developed.

Only 0.018% of the human population are intersex meaning there have a discrepancy between internal gonads and external genitalia or are atypical or ambiguous in their sexual development and have traits of both sexes male and female. Sometimes resulting in being more female or male in their sex development.

[haileyurias]

so many ppl in this comment section clearly did not understand/watch the video, your explanation was wonderful

[tanyaosterman]

You're too smart to get through to people who are willfully ignorant.

Excellent presentation of the facts!

[LeiaMisocky]

Thank you for this 👏🏼👏🏼 very late diagnosis of Swyer syndrome. Very informative and helpful! Keep up your amazing research and career! Bravo!

[oceanrocks]

People with XX male syndrome and XY Swyer syndrome are infertile and the reason for that, is because their chromosomes don’t align with their sex-determining genes. All males with XX male syndrome are infertile because they lack the other genes on the Y chromosome involved with sperm production. The same explanation also applies to those with Swyers, although they can get pregnant only through donated eggs (not their own), since their Y chromosome prevented them from developing ovaries which means their body naturally doesn’t produce the hormones to induce female puberty so they will have to take hormone replacement therapy.

[banelemakalima]

Please do more videos. All the best with being a doctor soon.

Great content!

[carlettagoodrich-mann]

Your Scentific review is clear and concise. Thank you for your disciplinary proven evidences.

[ausarmanntv]

Very informative video. @ 1:33 She said "disorders". This is less then 2% of the population. In no way should a society base their understanding about male and female sexual development on the abnormal 2% of the population. Genetics code for males and females only but mistakes happen.

[Tsithum]

Brand new information for me. Thank you!

[lacoperon]

I m so happy with this video clear and concise with lots of information ❤

[sunableflames]

Thank you for the clear explanation..I had to watch this video twice to understand it.
Please can you also explain Androgen insensitivity syndrome as it relates to Swyers Syndrome and CAIS.Thanks a lot.This will help me in understanding the nuances is these DSDs.

[techsalesandmore]

So you're saying a Y chromosome makes you male, unless you have one of those two syndromes. In which case they're assigned male or female according to their genitalia. Thanks for explaining it so clearly.😇 So is having either of those syndromes what's meant by being 'intersex' then? I hear this word being used a lot, and there's loads of unqualified opinions on you-tube. I'd appreciate your qualified opinion if possible?

[BB-dlzd]

So you still have only male or female.
You just have also males or female with sexual development issues. But still male or female

[Alrukitaf]

I’m sure it will be said that exceptions to the rule will happen. One should distinguish between that which is commonplace and what is rare. The guiding axiom would be to be kind to one another, despite the myriads of differences we may have. In general though, it appears that whilst there are a small percentage of exceptions, sex is determined by the presence or absence of the Y chromosome. The other issue of course, is identification of the Y chromosome. What is apparent is that there is a grey area here, and it seems the critical factor is that the information to produce testosterone, and penis etc. needs to be present, rather than just identifying the Y chromosome.

[nurahone]

I think the norm is XX is female and XY is male. Also the XY is phenotypically female for the first six weeks of formation. The anomaly’s are not the norm. The anomaly’s are a disorder.

[mandamank]

How do u get tested to see what your chromosomes are

[aarong]

They're still male they just didn't develop the outward appearance. Like a male lion without a mane or a tree that doesn't produce fruit.

[nurahone]

Isn’t that an anomaly to have have an XY female and a XX male?