Hemolytic Anemias- Part 2: SICKLE CELL ANEMIA- Pathology

Hemolytic Anemias- Part 2: SICKLE CELL ANEMIA- etiopathogenesis, clinical features, diagnosis & management

HEMOGLOBINOPATHIES
Clinical diseases that result from a genetically determined abnormality of the STRUCTURE or SYNTHESIS of the hemoglobin molecule.
The abnormality is associated with the globin chains
The heme portion of the molecule is normal.
SICKLE CELL DISEASE
Sickle cell disease is a multisystem disorder that is caused by a single gene mutation.
Group of disorders characterized by production of sickle hemoglobin ( defective hemoglobin) HbS
SICKLE CELL ANEMIA
Homozygous state caused by β-globin gene mutation.
Point mutation involving codon 6 of β-globin gene
This leads to the substitution of Valine residue for a glutamic acid residue resulting in sickle hemoglobin.

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[pavanjadhav]

Tomorrow is my micro patho exam.And the only reason I am confident about it is you.Thank you for your efforts sir😍❤️

[debigdogk]

Outstanding teaching, from a great teacher, thank you and thank you. Love from London ❤❤❤❤❤❤

[gaddamnavya]

Thank you very much for creating these wonderful lectures 😍

[slpbefl]

Thank you sirr for the clear explanation It helps so Your explanation is much more clearer than my lecturer’s explanation 😍😍😍

[lisaoney]

Finally found a cure for my son Sickle cell I’m so glad you came into my life. I pray for long life so you can save more souls, Thanks #uromi

[spoorthisrinivas.]

Cvs topics(MI, heart failure, rheumatic heart failure etc)

[Getrealpeeps]

Thank you for this info on Sickle Cell Anemia.

[shivanimaggon]

Thank you for the clear & in-depth explanation of the topic sir!

[DS-eqsi]

Sir, please make more videos, please. We PGs keep are immensely benefited by your videos. Please Sir🙏

[prabalmajumder]

Sir your presentation is just awesome ..very informative ..thanks

[DS-eqsi]

Sir, please make videos on lymph node pathology, including lymphomas, for PGs... a very kind request Sir🙏

[waelfadlallah]

Elaborate explanation sir thank you very much for the effort

[shivanisaini]

presentation is very good!!!!
thank you sir!!

[VimalKumar-zxhu]

Excellent teaching
Please, upload videos on other topics also.

LOVED THE PRESENTATION, THE ABSOLUTE WAY TO TEACH SCD

[furqanahmad]

Sir plz cover other chapters of robins basic pathology as well ...😊

[furqanahmad]

Sir plz make videos on the remaining pathology ..

[somalmeraj]

kindly complete all the types of anemias

[abinayam]

awesome videos, which was u put in youtube sir, put more videos for us sir

[abinayamurali]

Sir please upload video on thalassemia