Tolerance and withdrawal | Processing the Environment | MCAT | Khan Academy

Created by Carole Yue.

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[DocSnipes]

This is positively the BEST introductory explanation to tolerance and withdrawal that I have EVER seen. The rest of the videos in this series are also good, and would be appropriate for use in family education/treatment centers and graduate and undergraduate settings (I was an Assistant Professor at UF)...It is THAT good. I am not affiliated with the Khan Academy in any way. I came across their stuff while homeschooling my kids. Take a moment and watch the video and you will see what I mean...phenomenal.

[Beastosterone]

"May cause irreparable damage to other parts of your brain..." - key phrase

[johndoh]

This video helped me define addiction for me. It's good to know that I'm not addicted to porn/masturbation. I may feel a little more irritable and lethargic lately, but I don't feel abnormal or lower than my baseline of happiness

[skibitom]

Awesome video on mechanismof neurotratransmitters in the brain. Understanding tolerance and withdrawal would be the key to treatment addictions, mechanism of drug action.
I look forward for next video.

[cdvamp]

this is totally helping with my meth addiction.

[tomhanks]

Why are adult brains more resistant to drug addiction than younger people's brains? A nicely done video btw! 🤗

[MemoTea]

Orgasm addiction is the worst. It's free and very accessible. Only thing you need is a hand. It's an addiction you can never really beat.

[karachilovers]

Very impressive I like the voice of the girl as well as lecture too ❤ great style

[amberwilson]

so I’m currently in recovery from opioids. I am currently on methadone and have been for the past three years or so. I’ve been lowering my dosage and I have noticed that whenever I don’t lower it on a consistent basis, I feel intoxicated thus leading me to this video

[Dr.Pepper]

This is an excellent overview of addiction, and these principles apply to many drugs that replace the brain's normal production of the feel-good chemical serotonin. Once the drugs start to control the brain's production of serotonin, it takes a long time for the brain to take back over serotonin production once the drug is discontinued. Good job.

[aleksandar]

What if i develop total tolerance for realising emotions after workout (training for 5 yrs now) and tolerance after good lunch or any other healthy or less healthy activity, almost zero emotions released..any suggestions???

[juancarrillo]

I would wonder, or maybe there is a video on how the different drugs affect the brain unless they are all very similar in effects.

[Spacemonkeymojo]

Can't drugs also lead to an increase in receptors, which also results in withdrawal symptoms? Eg. too many drugs, brain or cells compensate by creating more receptors, due to there being more drugs, then when there are no drugs you get withdrawal.

Just did some research, seems to do with agonist/antagonist molecules, but tolerance and withdrawal can also be related to an increase in receptors (i.e. not just due to receptor desensitisation).

[ai_serf]

The science is definitely wrong. She starts out by saying that tolerance is such that you need more of the chemical for the same "effect", keyword being the same. I've never met an addict who says their first time could be replicated. From personal experience, the "effect" your looking for will never be achieved. Tolerance, addiciton, withdrawal are more nauanced and complicated than can be given in 5:32. I feel like this video is equivalant to: "learn how to solve PDEs with no math knowledge in 5 minutes".

Science is far behind on addiction, is that because of the underlying politics of racism and tyranny? I know the DEA(drug enforcement agency in America) has a policy that says, "regardless of science, illegal drugs will never be legalized".

SO maybe when it comes to the science of addiction, even scientists have their hands tied by the government.

[dejanmarkovic]

Wait, if the dendrite shuts down receptors in response ti a superstimulus of dopamine, how does a higher dose still get you high? Does it get crammed up through those receptors that are left open? I don't get it...if our brains are so smart to develop this thing called hedonic adaptation, why...oh, I see...adaptation...touche.
Ok, then how do multiple superstimuli affect the process of withdrawal? If you're kickin a drug, but you keep drinking, gambling, fucking, eating sugar, whatever...does it then alleviate the absence of that dug and make it easier to endure? Oooor....does it just reinforce your weak nucleus accumbence's habit of overindulging, eventualky ending up in a relapse? I don't know what region is responsible for what we call willppwer, but I imsgine it's somewhere in the pfc...so...do we spare it the pain, like an overworked muscle, or do we exercise it by every harmful habit that feels good? I don't get how it works and my ignorance manifests as this cyclic behavior because I don't know what the hell I'm supposed to do during abstinence...god damn it.

[emilecureau]

I don't think this video is very accurate.  One, meth incites release of dopamine from the presynaptic neuron, not coke.  Coke, afaik, blocks reuptake.  Secondly, tolerance isn't simply fewer active receptors, but also a myriad of other changes: higher CRF, lower dopamine secreted by the VTA, etc.   I like her previous video though on the mesolimbic reward pathway!

[lijcutube]

who else is here from treatment of substance abuse class at USC?

[friday]

Well im just here. Smoking weed. Stick to weed, no one has died directly from weed in any form.

[sarfarazahmed]

So boring.. please make it clear your words when you are saying.. be motivated and fast, I listened it twice and yawned.