Build a Better Brain: Reverse Cognitive Decline, Dementia & Alzheimer's with Dr. Dale Bredesen

Join Dr. Stephanie and her esteemed guest, Dr. Dale Bredesen, for an enlightening conversation that might just change the way you think about Alzheimer's. This episode is a treasure trove of brain and cognition knowledge that you won't want to miss!

This episode is truly a thought-provoking conversation about Alzheimer's and its unique impact on women with none other than the legendary Dr. Dale Bredesen (who is making his fourth appearance on the show). Dr. Bredesen, renowned for his groundbreaking work, holds an impressive academic background and has made significant contributions to neurology and Alzheimer's research.

Dale Bredesen, MD, received his undergraduate degree from Caltech and his medical degree from Duke University. He served as resident and chief resident in neurology at the University of California, San Francisco (UCSF) and as postdoctoral fellow in the laboratory of Nobel Laureate Professor Stanley Prusiner. He was a faculty member at UCLA from 1989 to 1994 and was then recruited by the Burnham Institute to direct the Program on Aging. In 1998, he became the founding president and CEO of the Buck Institute for Research on Aging and adjunct professor at UCSF. In 2013, he returned to the University of California, Los Angeles (UCLA) as director of the Easton Center for Alzheimer’s Disease Research and he is currently a professor.

Dr. Stephanie and Dr. Bredesen delve into the fascinating topic of Alzheimer's as a preventable condition, emphasizing that this is the first generation with the power to make Alzheimer's truly optional. They explore the shift in the common presentation of Alzheimer's, particularly in women, highlighting the rise of subjective or mild cognitive impairment in 52-year-old women.

Throughout the episode, they dissect various factors affecting the brain, such as mold toxicity, glyphosate exposure, and biotoxins, and their potential links to early degeneration. Genetics also take center stage, with a discussion on the ApoE4 gene and its evolutionary role in cholesterol metabolism.

As always, Dr. Stephanie and Dr. Bredesen provide actionable solutions for preventing and managing Alzheimer's, covering diet, exercise, sleep, supplementation, and testing. They introduce innovative blood tests, discuss the importance of a "cognoscopy," and even touch on dental health's role in brain health.

Resources Mentioned:

Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease - Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease


Episode Overview:
0:00:00 - Intro
0:02:27 - Welcome to Dr. Dale Bredesen
0:08:44 - Factors driving the shift in Alzheimer's disease onset age
0:12:26 - COVID-19 and Alzheimer's disease risk
0:22:25 - The role of diet in Alzheimer's disease
0:23:45 The postmenopausal women and cognitive decline
0:31:50 - Alzheimer's disease and genetic factors
0:33:35 How we could confuse perimenopause with Alzheimer's
0:41:24 - ApoE4 and the evolution of hominids
0:44:27 - ApoE4 and its pro-inflammatory effect
0:48:08 - The limitations of targeting neurofibrillary tangles and plaques
0:51:08 - Evaluating the efficacy of drugs for Alzheimer's treatment
1:01:24 - Exploring the use of supplementation in the trial
1:03:30 The seven fundamentals for maintain good brain health
1:10:42 - Importance of sleep hygiene and nasal breathing
1:15:23 Tailoring sleep habits to circadian rhythms and environmental factors

[elenabenjamin]

MAY GOD BLESS YOU AND YOUR WORK ! 🙏🏼🙏🏼

[Dreamopticsredlightglasses]

Thank you so much, another fascinating discussion, Dr Bredesen is so interesting, thanks 👍

[nda]

Thanks! Very interesting conversation!

[thelisteninglabs]

Super interesting podcast - thank you both. I recently read Brain Energy and then listening to you both - i love all the connections.

[lindajones]

This is tough to follow if you have never had a course in human anatomy and physiology .Forinstance , you need to know what fructose is, what the temporal and parietal lobes of the brain are.If you need more explanation try buying his book " The end of alzheimers".

[KimberlyADarling]

I am 64. Going mad. Quit Prozac two months ago. And hydroxezine, BRB…..
I cannot stop crying or control my rage( always home alone and directed inward—Depression is anger turned inward.)

I drove out to a ranch where the owner kept my lab pointer mix, and is going over rainbow bridge in Thursday—I couldn’t remember HOW TO GET THERE!

Listening.

I hope I can add your protocol to the things (exercise and supplements and doing KETO, I’ve begun.

[Healingandchoices]

I appreciate the mention of owls vs larks. One can't force oneself to adjust sleep patterns.

[bettyhirsch-klein]

Use natural cleaners vinegar baking soda hydrogyn perixide etc

[bettyhirsch-klein]

I have little knowledge medical terms. But this helps your brain to learn and aquire new info.
We are products of genetically modified foods, pharmaceuticals stress. Need to change lifestyle. I first went off sugar for 2 weeks. Feel better already

[jaynarang]

Sulphurane
Green leafy
Gut health
Estradiol
Progestroone

[smartindian]

I appreciate great knowledge of all Doctors👍Tell us in few simple sentences, what I should do? Simple Simple 😂😂😂😂😂😂😂😂

[RuthWeaver-vh]

So many terms talked about are out of my knowledge. Thus I am not getting the
information I need to reverse my mci

[gretchenbond]

I was looking forward to listening to this. I have read The End to Alzheimer's and I feel like you are talking around the solutions. It's very frustrating. I had to stop listening.

[RuthWeaver-vh]

We need a cookbook from you. I cannot afford the delivered meals please help.i have mci and am in your recode program.i
Need to know what to eat.

[Dreamopticsredlightglasses]

Dr Bredesen mentioned salts and esters (?) what are these? does he mean salt? what is an ester? what food is it found in? thanks

[luckssj]

Hi, I take 72 macro/micro nutrients, 80 grams of fiber, Nitric Oxide, 24 hour vitamin C, Hormone D3 15, 000, krill oil omega 3, NMN and Fisetin. I think that I am doing good? What is your opinion?

[KimberlyADarling]

I have MCT oil—good brand
What about exogenous ketones? Too much salt?

[WilkinsCharlotte]

I love Dr Bredesen but you may need a dictionary to learn what some of these things that he talks about. It can be very confusing.

[Nottherebutthere]

Too many unexplained acronyms. Guess this is meant for other doctors.

[patriciastubbs]

Too much doctor talk. I couldn't follow the conversation.