Physics of flow networks (Lecture 1, Remote talk) by Karen Alim

Program

ICTP - ICTS Winter School on Quantitative Systems Biology

ORGANIZERS: Buzz Baum, Guillaume Salbreux, Stefano Di Talia and Vijaykumar Krishnamurthy

DATE: 03 December 2019 to 20 December 2019

VENUE: Ramanujan Lecture Hall, ICTS Bangalore

The development of an organism from a single-celled zygote to an embryo involves a tight integration between gene expression, signalling and mechanochemical processes. In recent years, there has been an explosion in studies that attempt to unravel the physical principles behind how organisms self-organize to generate their three-dimensional shape and functional form. Novel microscopy techniques are giving unprecedented views into the processes of development at very high spatiotemporal resolution. This deluge of data necessitates a larger scale systems-level understanding how organisms build themselves.

The eighth edition of the ICTP - ICTS winter school on quantitative systems biology is focussed on Morphogenesis and will enable students from different backgrounds to become familiar with exciting developments at the interface of Physics and Developmental Biology. The participants of the school will be exposed to contemporary research areas, covering a large variety of topics, including mechanochemical pattern formation, regeneration and growth regulation, evolutionary-developmental biology. The school will emphasize how major questions in developmental biology such as stem cell differentiation, morphogenesis, tissue patterning and tissue mechanics, can be asked with the help of quantification and physical theory.

The main school will be held between December 9-20, 2019 and will be preceded by a pedagogic and intensive ‘Pre-School’ between December 3-6, 2019. The Pre-School will cover the basic concepts in cell and developmental biology and will have short modules on mathematical modelling and physical approaches to biology.

Scientists and students from all over the world can apply for the School. Researchers from developing countries are particularly encouraged to apply. As the program will be conducted in English, participants should have an adequate working knowledge of this language. The subsistence expenses of all selected outstation participants will be borne by the School. As a rule, travel expenses of the participants should be borne by the home institution. Every effort should be made by the candidates to secure support for their fare. However, limited travel grants are available to support the attendance of participants from developing countries from Pratiksha Trust scholarships, ICTS, Bengaluru. Selected participants are expected to attend the entire main school. Selection for the main school automatically guarantees selection for the pre-school, but attending the pre-school is not compulsory. There is no registration fee.

Organizing COMMITTEE

Buzz Baum (University College London)
Stefano Di Talia (Duke University)
Vijay Krishnamurthy (ICTS, Bengaluru, Local organizer)
Guillaume Salbreux (Francis Crick Institute)

SCIENTIFIC ADVISORY COMMITTEE

Vijay Balasubramanian (University of Pennsylvania)
Antonio Celani (ICTP Trieste)
Sanjay Jain (University of Delhi)
Matteo Marsili (ICTP Trieste)
Mukund Thattai (NCBS Bengaluru)

Previous editions of this school :

2018, 2017, 2016, 2015, 2014, 2013, 2012.


0:00:00 Physics of flow networks (Lecture 1, Remote talk)
0:01:51 Fluid-filled networks abundant
0:10:05 Model organism is network-shaped giant cell
0:17:55 Contraction wavelength scales with network size
0:21:28 Contraction driven transport: peristalsis
0:29:16 Tube - linear phase gradient, single period optimal
0:32:01 Conservation of mass constrains phases
0:34:46 Peristalsis in a network
0:36:15 Peristaltic wave for efficient transport by Taylor dispersion
0:37:54 Tube hierarchy affects transport
0:39:32 Pruning to increase Taylor dispersion
0:43:01 Derivation - Dynamics of transport in networks
0:43:20 Transport of email particles
0:45:05 Taylor Dispersion
1:24:20 Q&A