Understanding the Infective Stage of the malaria parasite | Photini Sinnis, MD

Embark on a journey into the intricate world of malaria research with Dr. Photini Sinnis in this video titled ""Understanding the Infective Stage of the malaria parasite."" Dr. Sinnis, who leads the Sinnis Lab at the Johns Hopkins Malaria Research Institute, focuses on unraveling the mysteries surrounding the sporozoite stage of Plasmodium—the infective stage of the malaria parasite.

Research at the Sinnis lab targets the stage when the parasite is vulnerable. From emerging from oocysts on the mosquito's midgut wall to navigating through human skin via mosquito saliva, sporozoites reach their destination in the mammalian liver. The Sinnis Lab's research specifically investigates the trajectory of sporozoites in the skin after inoculation.

Key highlights of this presentation include:

In-depth exploration of the infective sporozoite stage of the malaria parasite
Understanding the vulnerability of the parasite during this crucial stage
Insights into the journey of sporozoites from mosquito to mammalian liver
Microscopy showcasing the intricate process, courtesy of Dr. Sachie Kanatani, whose work earned recognition in the 2021 Nikon Small World competition.
Watch the video to witness the microscopy capturing the transfer of 10 to 200 inoculated sporozoites during a mosquito bite, into a human being.

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