Staphylococcus aureus Sepsis: Crucial Tips for Clinicians

The only way to successfully treat sepsis caused by S. aureus. When dealing with infections caused by S.aureus, everything has to be done right: The choice of antibiotics, the duration of treatment, screening for complications like endocarditis and metastatic infections, source control, follow-up blood cultures, and much more. Even with modern drugs, Staphylococcus aureus bacteremia still carries a mortality rate of 25%, but there is a lot we can do to increase our patients' chances.
If you want to make sure you recognize life-threatening infections like sepsis and CNS infections in time, you will find invaluable tips in my short, practice-oriented lectures!

A Clinical Approach to Serious Infections in Adults: What Every Physician Should Know:

DISCLAIMER: Please, always keep in mind that my videos are intended for educational purposes only. The content of my videos is NOT medical advice. I do not practice medicine over the internet. If you are a patient and have any questions about your health, please talk to your doctor.

CHAPTERS:
00:00 What makes S. aureus special
01:49 Empiric and definitive therapy for S.aureus (MRSA vs. MSSA)
04:09 Blood cultures and other microbiological samples
05:14 What antibiotics are best for MSSA
05:52 The duration of treatment
06:28 Look for endocarditis and removable foci of infection
07:59 The final tip

REFERENCES & RECOMMENDED READING:
1. Lam JC, Stokes W. The Golden Grapes of Wrath - Staphylococcus aureus Bacteremia: A Clinical Review. Am J Med. 2023 Jan;136(1):19–26.
2. Heffernan AJ, Sime FB, Lim SMS, Adiraju S, Wallis SC, Lipman J, et al. Pharmacodynamics of ceftriaxone for the treatment of methicillin-susceptible Staphylococcus aureus: is it a viable treatment option? Int J Antimicrob Agents. 2022 Mar;59(3):106537.
3. McDanel JS, Perencevich EN, Diekema DJ, Herwaldt LA, Smith TC, Chrischilles EA, et al. Comparative effectiveness of beta-lactams versus vancomycin for treatment of methicillin-susceptible Staphylococcus aureus bloodstream infections among 122 hospitals. Clin Infect Dis. 2015 Aug 1;61(3):361–7.
4. Goto M, Jones MP, Schweizer ML, Livorsi DJ, Perencevich EN, Richardson K, et al. Association of Infectious Diseases Consultation With Long-term Postdischarge Outcomes Among Patients With Staphylococcus aureus Bacteremia. JAMA Netw Open. 2020 Feb 5;3(2):e1921048.

[clinicaltips]

I want to remind everyone that my videos are for educational purposes only. Of course, everyone is welcome to watch, but the information I present is most useful for junior doctors, nurses, and students. As I stated in the description of every video and on my channel homepage, none of this is medical advice for patients. I don't practice medicine over the internet. If you are a patient and have any questions about your health, please get in touch with your doctor.

[glenntankard]

I had staph aureus lodged in my neck vertebrae, cervical epidural abscess. It was so severe I had a complete laminectomy to drain it but unfortunately the infection damaged my spinal cord. I was paralysed as a result, spent 6 weeks with a pickline antibiotics and had to learn to walk again. If you have bad neck pain go straight to hospital emergency and get bloods and an MRI scan as that’s the only way to diagnose MRSA

[pauloconnor]

My son is dealing with this now both useful and terrifying at the same time.

[deliriousanne]

Love your lectures!!! Great! Thank you very much! I include your lectures and tips in my everyday practice and it helps a lot.

[breaux]

My father died with this. They didn’t even try to help him. He had no spleen. They just let him lay there and then when he passed, they asked me for body parts. To this day I am disgusted with this practice. He’s not well enough to take the surgery, and they refused to do anything.

[Philmoon]

Thank you so much for your detailed information and references! Your video had all the information I needed, and it could use the references that you provided! Keep up the great work!! Cheers

[anonymousperson]

This video was HUGELY informative and likely saved many lives if the advice here is followed.
Thank you for posting this!!!

[stephanieluben-jfxh]

My dad has been on Antibiotics for 5 days in hospital nothing has changed the infection isn’t going and his fever won’t go down his blood pressure is through the roof his😢 praying he will come out of this

[Hotwire_RCTrix]

15 years ago I contracted a staphylococcus infection while on holiday in Egypt. It created terrible ulcers that persisted for years. You never get rid of this bug but knowing you have it is a huge plus.
On the outside it's not a problem but inside it's very nasty. Most GPs will treat you like a pest but you need to use a doctor that understands how important this is.
I almost had to have my foot amputated a few years ago because a young GP refused antibiotics.
This isn't a trivial bug.

[jataufwangshak]

From the very first time I started seeing testimonies about you Dr igho, you gave me full that confidence that I had purchased your medicine, my hiv test would be was negative, now I'm so happy that I could finally have a healthy life thank you so much Dr you really are a Godsent and i appreciate you a lot

[nicolajane]

I caught this miserable infection after my cancer treatments. I had a mastectomy and it developed badly after two months. This was 2017. Since ive had to live with this. Ive only been given two weeks tops of antibiotics but its done nothing. It keeps coming back. Now i have breathing problem's and cant walk. I am so scared and dont know which way to turn.

[glenntankard]

I forgot to mention if you believe it's in your son's neck vertebrae then he will need an MRI to diagnose this, a CT scan does not show up a cervical abscess. Go to hospital for this and make urgent request

[freman]

Can we swim in the ocean to clean the wounds if we have staph infection?

[TechwithStefan]

very good explanation dr.Viktor, can i ask: for a patient with staff infection, that had a stroke, than complications like endocarditas and holds water in the lungs and heart, what should be the best advice?

[Jakcda]

I just lost my dear dad a few days ago due to this bacteria. He was gone within 2 days, doctors said there was no way for him to get better.

[taylortabasco]

What should someone take if allergic to vancomycin?

[thsNGunz]

Why won’t doctors treat people who have it? They make excuses for not treating anyone who has these symptoms and it’s just wrong on all levels

[lindanorris]

regular coconut oil will wipe out staph...I am living proof of this.

[MB-biqu]

I had problems because of the staphylococcus. I did a parasite cure and stopt eating sucre. I eat only not prossed food. I do only pro biotics!