Is It Possible To Prevent Heart Attacks in Women? Hormones Are The Key

The Women's Health Initiative showed that conjugated equine estrogens (CEE), along with a progestin called medroxyprogesterone, increased heart disease risk in women. But how strong is that evidence?

This review, by Steve Goldring, The Hormone Pharmacist, focuses on evidence directly from the WHI, as well as from other large-scale trials about menopause hormones to answer the question: Do menopause hormones increase heart disease risk? Or do they reduce it?

Should you take HRT for menopause? If that question feels impossible to answer, I'm here to help. My digital course, The Menopause Solution, guides you through Searches, Stories, and Studies to help you make your HRT decision.

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Tags
#progesterone #estradiol #medroxyprogesterone #premarin #progestin #bioidenticalhormones, #heartdiseaseinwomen #conjugatedestrogen #cee #heartattackwomen #naturalprogesterone #womenheartattack #micronizedprogesterone #bioidenticalprogesterone #menopausehormones #menopausalhormonetherapy #womenshealthinitiative #bioidenticalestrogen #benefitsofhormonereplacementtherapy #oralestradiol #hormonereplacementtherapymenopause #timininghypothesis #estradiolmenopause #hrtreview #progesteronemenopause

References
Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J; Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002 Jul 17;288(3):321-33. doi: 10.1001/jama.288.3.321. PMID: 12117397.

The Danish Study or DOPS - Danish Osteoporosis Prevention Study (2003)
Jensen L., Vestergaard P., Hermann A., Gram J., Eiken P., Abrahamsen B., et al. (2003) Hormone replacement therapy dissociates fat mass and bone mass, and tends to reduce weight gain in early postmenopausal women: a randomized controlled 5-year clinical trial of the Danish osteoporosis prevention study. J Bone Miner Res 18: 333–342.

KEEPS - Kronos Early Estrogen Prevention Study (2019)
Review The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?
Miller VM, Naftolin F, Asthana S, Black DM, Brinton EA, Budoff MJ, Cedars MI, Dowling NM, Gleason CE, Hodis HN, Jayachandran M, Kantarci K, Lobo RA, Manson JE, Pal L, Santoro NF, Taylor HS, Harman SM
Menopause. 2019 Sep; 26(9):1071-1084.

ELITE - Early versus Late Postmenopausal Treatment with Estradiol (2016)
Hodis HN, Mack WJ, Henderson VW, et al. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol. N Engl J Med. 2016;374(13):1221-1231.

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[squirrlee]

It’s so important to have reputable professionals who aren’t hawking snake oils AND are male… who support and share data-backed science behind the importance of female hormone replacement. Thank you !!

[cm]

Your videos are so valuable! Thank you so much. I love that you give us the evidence-based facts, and dissect and explain the studies to us. We can forward your videos to our healthcare professionals who are in the “dark” and therefore often unwilling to properly help menopausal women.
The main thing that needs to change, in my opinion, is EDUCATION about menopause and associated health risks.

[elizabethpreciado]

So I’m 63 yo I’ve had high cholesterol x 10 yrs. Other than that I DONT have diabetes, high b/p, NOT over weight at all. I’ve always kept my wt at my ideal wt range. My gynecologist from Kaiser refused to prescribe bio identical HRT because of my age and menopausal 12yrs. And she also said from very RECENT STUDIES showing that it can cause heart disease, A THIKENING OF THE ARTERIES. But I’m seeing a gynecologist outside of Kaiser and she didn’t agree with the Kaiser gynecologist, so I’ve been on bio identical HRT for about 3 months now. But the Kaiser gynecologist put the fear on me, and I do worry if I’m doing the right thing. WHAT ARE YOUR THOUGHTS? THANK YOU!!

[shaynebetts]

Thank you Steve, excellent information.

[Aki-wqxh]

I am confused. If I missed the window will it cause any HARM? I don’t mind less benefits but I don’t want more harm.

[amylee]

do you do one-on-one consultations with patients?

[elainelerma]

Wow! Thank you so much! I want to take HRT I had a heart attack 8 years ago. I am now 51 thin and strong. I eat right and work out daily. Am I a candidate for HRT? I really want to start on it like now. Please send me your answer.

[janicemccoy]

I’m 75, I stopped taking HRT when that study was done, I recently started taking bio identical hormones 3 months ago. I know I have missed the so-called window of opportunity, is it too late for HRT to help me? My, bones, heart, and mind, am I just wasting my money or what can bioidentical hormones do for me now? Thanks in advance.

[selato]

How do you feel about taking bioidentical hormones if you already have heart disease?

[carolwyban]

I began reading the work of Dr. John Lee. A lot of good information.