The Hallmarks of Aging: Stem Cell Exhaustion | LifeXtenShow

Your cells don’t last forever; for one reason or another, they pretty much all die and need to be replaced. This is the job of stem cells, the "cellular students" of your body that specialize into specific types of cells and repopulate your cellular workforce. But what happens when your body runs out of students?

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Sources:

The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.

Telomerase expression in stem cells

Link between pathologies of aging and stem cell exhaustion

Stem cell exhaustion and immune function decline

Link between pathologies of aging and stem cell exhaustion

Link between genomic instability and stem cell exhaustion
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007). Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature, 447(7145), 725.

About stem cell niches
Ferraro, F., Celso, C. L., & Scadden, D. (2010). Adult Stem Cels and Their Niches. The Cell Biology of Stem Cells, 155–168.

Stem cell injections against aging frailty
Tompkins, B. A., DiFede, D. L., Khan, A., Landin, A. M., Schulman, I. H., Pujol, M. V., ... & Mushtaq, M. (2017). Allogeneic mesenchymal stem cells ameliorate aging frailty: a phase II randomized, double-blind, placebo-controlled clinical trial. The Journals of Gerontology: Series A, 72(11), 1513-1522.

About stem cell transplants

About stem cell transplants

Gutierrez-Aranda, I., Ramos-Mejia, V., Bueno, C., Munoz-Lopez, M., Real, P. J., Mácia, A., … Menendez, P. (2010). Human Induced Pluripotent Stem Cells Develop Teratoma More Efficiently and Faster Than Human Embryonic Stem Cells Regardless the Site of Injection. STEM CELLS, 28(9), 1568–1570.
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#StemCells #CellTherapy #Aging #MolecularBiology #Biology #LifeExtension

[BrentNally]

Great analogy with the students and specialized cells!

[Danath]

Another fantastic episode! Very informative, and very reassuring to know that stem cell research is one of the areas that is not suffering from funding issues that plague equally important hallmarks that need to be addressed.

[volarealto]

Great stuff! I would speculate that the work the Mike and Irina Conboy with blood dilution, it removes the factors in the blood that impedes the re-creation of stems cells.

[sepnax]

Super interesting stuff. I've been lately really interested in stem cell division and development so the video is much appreciated.

[PaulBeauchemin]

I’ve heard GDF11 May revise stem cells. Thought?

[iamkhaosolympus]

Mines aren't that is weird I've watched people who were children have children and get old and ugly lol I'm must not be a human lol I have a wall around my immune system as well so I can not get sick never had never will I have unlimited energy in my body I wonder if its radiation because I interfere with electrical devices of all sizes

[crafteru]

in the works ba humbug i will be dead before its available