Dr. Sinclair’s New Theory of Aging, Explained.

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[sabincioflec]

Petition for a video on demon possession and longevity in mice.

[homesignup]

This is a fantastic study and thanks for your breakdown analysis. I totally agree - and this now explains past studies that indicated that only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in environment and lifestyle eg smoking, diet, alcohol, UV, pollutants, infections, stress, obesity, physical inactivity. Looking fwd to more on human studies too and your analysis. I will share this with my friend who is a genomics principal scientist.

[ThatOneScienceGuy]

I'm glad to see you give credit to how hard molecular biology is. When I was in undergrad for biology, it was the most challenging course.

[Physionic]

Put a lot of work into this one - hope it’s clear and informative. If you have related questions, feel free to ask.

Also, I know nothing about the NMN situation and Dr. Sinclair. This is merely an evaluation of his largest scientific work.

[paninopanini]

These subjects are soo hard to explain, even to stem field students. I admire how you wanted to share this information in a more "people in general friendly" manner. Amazing how many aspects of aging is in our hands. I wonder how technology, if any, have a impact in our epigenome, the constant use of our phones and social media I think can make a impact in some way. what a great video

[elliottdebell]

Has Sinclair not been shamed out of science yet, as a low rate salesmen? He sold his research for a huge sum to GSK which then couldn’t be replicated by any of the other researchers. which tells me he had bias and ego leading his research. He also lied about other researchers not consulting him before they started which was not true. I take everything from that man’s mouth with a pinch of salt! Love your videos though 😊

[wilmerwalton]

Your presentation was outstanding. Just as my head began to hurt, you injected a bit of comic relief, then got right back into it. I appreciated the conclusion where you informed us that we should keep doing what we already know we should be doing to maintain our health. As is your practice you left me wanting more, much more.

[roblake]

The Epigenetic cause of aging has been shown in multiple ways. Working with fish, this evidence has become more specific. Even perfect RNA cannot make protein/peptides/hormones without having all necessary amino acids. The current evidence points to a lack of amino acids due to changes in the microbiome. It looks like their may be a universal overgrowth of parasitic bacteria over time. Humans can have trillions more of specific gut bacteria as they grow older. After all, old people appear to be starving...

[maxicathnry]

Great study, but honestly I would rather age than mess with my 😢dna, I swear by saunas and fasting for maintain a youthful appearance 😢 would you do a natural follow up on aging looking at what I’ve mentioned plus other scientific backed research 🔬

[Draziell]

These new videos that you breakdown the science are the best!! Please keep doing it!!

[liamh]

Do you believe this New Theory by Dr Sinclair will eventually provide a supplement more successful than say Resveratrol and NMN, I’m sure GSK is not as excited as yourself. 😂

[rayfleming]

How big of a roll does epigenetic tagging play with cancer versus genetic mutation. I worked as a health physicist and our story was the cancer being caused by generic mutations. But the fact that many people get the same types of cancers means it could not be due to strictly random mutations. Epigenetic differences could be a better explanation for how cancer types are so reproducable.

[TNT-kmeg]

Let me tell you something Mr . You can jump as much as you want, time you're never going to turn back . Stretch, stretching, stretched . The end is always the same : by, by .

[Nanamowa]

It's been pretty well understood for a while now that getting the wrong histones in a cell for that cell type is a major cause of aging, especially as it relates to health span. Epigenetics is very important.

[buybuydandavis]

I like the demon possession theory of aging.
Implies that all we need to live forever is an exorcist.

This was fantastically presented. Thank you for the information presented in a clear way.

[vsalukir]

Frankly, I don't trust Sinclair. And I'm betting that his answer is going to be some product for which he has the patent.

[Andrew-W]

Great presentation as always nicolas. It makes sense now that the "epi-" in front of genetics meaning on top - may actually refer to these "tags" you refer to.

I am always ambivalent on topics involving NAD precursors supplements. While my biochemistry is admittedly pedestrian, there appears to be perplexed findings on their use on present literatures (particularly B3/NMN/NR and or even Metformin). Perhaps food for thoughts in the future?

many thanks. live-it-forward, AW.

[photo]

Great video, thanks. So the primary takeaway is that David Sinclair has demonstrated that epigenetic damage is more likely to be causing gradual aging than gene damage.

The secondary takeaway is that Yamanaka factors can potentially reverse some of this epigenetic damage, but are too dangerous to use, presumably because if you overshoot, you end up converting everything to stem cells..?..

So, a few questions:
1. How were the Yamanaka factors controlled in the experiment, so as to unwind the epigenetic damage without damaging the mice?
2. How will this affect the direction of research? Will it focus on how to safely use Yamanaka factors, perhaps by only using some of them? Or are there other methods that show promise?

[larsnystrom]

If Sinclair belives that he can make mice younger. Why does he have to damage them first?
Why not just make naturally old mice younger?

And if he damage some mice and repair them. Does they live longer than damaged but not repaired mice?