Sulforaphane Extends Lifespan, Increases Muscle Strength And Endurance

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Papers referenced in the video:

Sulforaphane prevents age-associated cardiac and muscular

Evaporative Light-Scattering Analysis of Sulforaphane in Broccoli Samples:  Quality of Broccoli Products Regarding Sulforaphane Contents

Biochemical composition of broccoli seeds and sprouts at different stages

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress

[conqueragingordietrying]

In the video I mentioned a "potential HEV". But, it's possible that calculation needs to account for body weight. If so, the equation would be:

(442.5 * 0.004)/0.04 (aged mice weigh ~40g) = 44.3 mg SFN/kg BW

Then, accounting for the body size conversion from mice to people, 44.3/12.3 = 3.6 mg SFN/kg BW in people. For my BW (64 kg), that = 230 mg of SFN/d, not 144 mg of SFN/day.

[EVanDoren]

Interesting. I grow my sprouts, but had no idea that sulforaphane content increases. I was harvesting them too soon.

[ksb]

Subscribed. One of the best youtube videos on the subject of sulfurophane

[eruiluvatar]

The study about the massive increase in muscle endurance for old mice is quite interesting to me. Back in 2019 I was extremely sick with what I now know to be mast cell activation syndrome. One of the symptoms was terrible endurance that paradoxically would improve a lot after 3 days or more of fasting and I also discovered that sulphoraphane produced the exact same improvement in me. The improvement was most noticeable in anaerobic exercise, the repetitions to failure on bicep curls jumped from 11 to 16 and did so consistently. My current thoughts on that was that the effect is mediated by lowering gut inflammation or directly calming mast cells and that having an effect on the autonomic nervous system and other stuff that goes wrong downstream like blood pressure and electrolyte concentration but maybe it has a more direct effect. Anyway sulforaphane is great and it is one of the few things that helped me.

[joevs-tbiw]

Try adding mustard powder to your sprouts as a method to reduce broccoli sprout amount requirement. Here is the study: Supplementation of the Diet by Exogenous Myrosinase via Mustard Seeds to Increase the Bioavailability of Sulforaphane in Healthy Human Subjects after the Consumption of Cooked Broccoli
Olukayode Okunade et al.

[KJ-umgq]

Have you looked into moringa powder, Doctor? It said to boost NRF to even more significantly than sulfuraphane, and it’s readily available in powder form at most health food stores.

[Klaudiuszeg]

Great channel, its like encyclopedia.
SO i think polish dishes are not so bad afterall, we eat a lot of cabbage that also has Sulforaphane

[iriez]

The video fails to mention that you need Myrosinase for conversion of sulforaphane in the gut, which heat destroys. So if you go the broccoli route you need to eat raw or mix with mustard seed / extract.

Also as Rhonda Patrick has pointed out you can double sulforaphane content in sprouts by supplementing woth calcium while growing and you can potentiate the Myrosinase by freezing the sprouts immediately after growing, massively increasing bioavailability.

[edwhite]

I was surprised to see the reduction and then increase in sulfurophane in broccoli sprouts. Previous info that I had said it was highest shortly after they sprout

[peterz]

Thanks. I have a sprout kit too. Nrf2 - Other impacts: from my spreadsheet (PubMed based) i see that TRE and DR also raise Nrf2. Curcumin, ginger, and cocoa as well. Magnitude ? Other interventions? don't know but worth me rechecking. Important pathway. Point being that we don't need to rely totally on broc sprouts. I also rely on eating a lot of other cruciferous vegetables (Brussel sprouts, etc).

[Seeker_of_sense]

I would like to add that Nrf2 activation can contribute to tumor development and progression by promoting cell survival, proliferation, and resistance to chemotherapy and radiation therapy. For example, a study has shown that sulforaphane made colorectal cancer grow faster. NRF2 promotes the tumor's response against ROS and thus survival. So I am not sure how smart it is to activate it. There's quite a few chemotherapy trials using NRF2 inhibitors.

[margaritorendonortiz]

Could be possible to get sulforaphane from the cabbage juice?

[aquamarine]

I used to buy broccoli sprouts, combined with radish sprout to multiply the sulforathane (a Rhonda Patrick trick, IIRC). But it's so expensive, and there's always a chance raw sprouts contain e-coli. I'm content to simply add mustard seed powder to my cooked cruciferous vegetable (Broccoli, brussell sprouts, red cabbage or cauliflower). I eat about 400-500 g of those, two meals per day.

[timwilliams]

Just started a Sulforaphane supplement by brocoelite its from the doctors who worked at Johns hopkins and it contains 5MG of Stabilized Sulforaphane and they suggest one or two a day so a max of 10 MG. Which is Much lower than the equivalent dose the Mice were on in the study. Also these are not CHEAP . I do NOT like the taste of Broccoli sprouts and have tried that in the past and did not find it sustainable to keep doing that every day, Would love to see you try the SEEDS which i would think would be the easiest and most sustainable way of getting this much sulforaphane in the diet. Just noticed that the broco elite also has 325MG of broccoli seed COMPlex per capsule so that is a max of 10MG of Sulforaphane plus 650 MG of Broccoli seed extract . would you consider doing a study on this new supplement? its unique in that it contains Stabilized sulforaphane

[Always-xldb]

One thing though, because you have hypothyroidism, is to closely monitor thyroid hormones because of potential disruption due to its action as a goitrogen and competing with iodine uptake.

[ChessMasterNate]

Could you post some pictures (or vid) of your sprout farm, any other foods you are growing yourself, and maybe some plates of food you eat?

[mightbeanybody]

Plus SFN intake from 2 weeks before to 4 days after the exercise increases NQO1, a target gene of Nrf2, and suppresses DOMS after 2 days of eccentric exercise. And, aerobic-resistance training and SFN supplementation reduces cardiometabolic risk factors. SFN improves insulin resistance, is antioxidative and anti-inflammatory.

[shonufftheshogun]

I use moringa powder from a purely convenience perspective. I realize it’s not exactly the same but it’s cheaper and easier.

[dove]

It's hard to measure the weight of home-grown sprouts unless you really dry them out. It will take a lot of sprouts to reach 100g. They have a sharp, bitter taste that you can quickly tire of, so best to disguise it in something with strong flavors, e.g., lemon, garlic, or tomato. Tastewise, it would almost be easier to eat ten times the weight in mature broccoli.

[mightbeanybody]

Hmm, the capsules I have only contain 400mcg per. Change required.