Fix AMD Catalyst Control Center not opening in Windows! Error 41? (2023 Updated)

Here are some things to try if AMD Catalyst Control Center is not opening in Windows:

- Update your graphics drivers to the latest version. Old or corrupt drivers can prevent Catalyst Control Center from launching.

- Restart your computer after updating drivers. This ensures the new drivers are loaded properly.

- Uninstall and reinstall Catalyst Control Center. This can fix registry or file issues with the app.

- Run Catalyst Control Center as Administrator. Right click and select "Run as Administrator" to launch with elevated privileges.

- Temporarily disable antivirus software. Some antivirus programs block Catalyst Control Center from running.

- If using multiple AMD graphics cards, make sure Crossfire is disabled. Crossfire issues may prevent Catalyst from opening.

- Check for Windows updates and install any available updates, especially those for .NET Framework.

- Try deleting the AMD folder located at C:\Program Files (x86)\AMD and reinstalling Catalyst Control Center.

- Use DDU (Display Driver Uninstaller) to do a clean uninstall of AMD drivers, then reinstall the latest version.

- As a last resort, reset Windows which will reinstall all drivers and system files.

i. Here is a list of some common AMD Catalyst Control Center error codes and potential fixes:

- Error 41 - Failed to start device. Try reseating the graphics card, updating motherboard BIOS, disabling hybrid sleep.

- Error 43 - Graphics card not detected properly. Check PCI-E connections, try uninstalling drivers with DDU and reinstalling.

- Error 195 - Cannot apply selected settings. Reset CCC settings to default then reconfigure.

- Error 197 - Catalyst Control Center version mismatch. Uninstall and install latest supported version.

- Error 198 - Unable to load necessary files. Reinstall/repair CCC through Programs & Features.

- Error 199 - Graphics card not supported by this version. Upgrade to latest CCC version.

- Error 221 - Cannot enable Crossfire. Check GPU seating, Crossfire bridges, disable Crossfire retry.

- Error 304 - Unable to load overlay ICC profile. Reset CCC to defaults.

- Error 305 - Conflicting UPLS profile detected. Reset CCC colors to default.

- Error 2001 - Region mismatch. Make sure CCC region matches AMD driver region.

I'd recommend first trying resets to CCC defaults or uninstall/reinstall. Update graphics drivers if needed. Check AMD's online resources for any other specific error codes you encounter.