Protein Degraders

Protein degraders are leverage the ubiquitin-proteasome system (UPS) to change the destiny of disease-causing proteins. Usually small molecules with two active ends, one that binds to the protein of interest (POI) and the other that binds to a protein called E3 ubiquitin ligase. These bifunctional molecules force a handshake between the ubiquitin and the protein, sending it to the trash.

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