New Frontiers in Targeted Protein Degradation and Degrader Development

The use of heterobifunctional small molecule Degraders (e.g. PROTACs, SNIPERs etc) to elicit targeted protein degradation (TPD) is an area of increasing interest in chemical biology. They offer an attractive approach for inducing selective protein knockdown in a reversible and tuneable manner, without requiring genetic modification of cells. This is currently an area of tremendous interest, offering a potential new approach to tackle the ‘undruggable’ proteome and overcome common resistance mechanisms to current therapies.

This webinar provides an introduction to Targeted Protein Degradation, discussing design and optimization of Degrader molecules and how structural biology and rational design can shed light on the Degrader development process. The second section of the webinar will present the dTAG platform for target validation. dTAG molecules specifically recognize and degrade FKBP12F36V fusion proteins, presenting a new platform for target validation studies.