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A Guide to Comprehensive Epigenetic Analysis
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A Guide to Comprehensive Epigenetic Analysis
Disclaimer :
Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research.
Fair use is a use permitted by copyright statute that might otherwise be infringing.
Non-profit, educational or personal use tips the balance in favor of fair use.
#Science #Technology #Invention
Next-generation sequencing technologies have helped scientists establish causal relationships between genetic aberrations and disease. Researchers have expanded sequencing technologies to detect epigenetic modifications and study their links to disease through epigenome-wide association studies (EWAS). Such studies typically use bisulfite sequencing to detect DNA methylation, but this technology cannot distinguish between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), two important DNA-based epigenetic modifications.
Download this application note from Tecan to discover How to detect DNA methylation and hydroxymethylation with the TrueMethyl oxBS Module
Methods for performing comprehensive epigenome-wide association studies that analyze both 5mC and 5hmC levels
How researchers applied TrueMethyl oxBS to detect an abnormal epigenetic signature in multiple system atrophy (MSA) patients
Disclaimer :
Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research.
Fair use is a use permitted by copyright statute that might otherwise be infringing.
Non-profit, educational or personal use tips the balance in favor of fair use.
#Science #Technology #Invention
Next-generation sequencing technologies have helped scientists establish causal relationships between genetic aberrations and disease. Researchers have expanded sequencing technologies to detect epigenetic modifications and study their links to disease through epigenome-wide association studies (EWAS). Such studies typically use bisulfite sequencing to detect DNA methylation, but this technology cannot distinguish between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), two important DNA-based epigenetic modifications.
Download this application note from Tecan to discover How to detect DNA methylation and hydroxymethylation with the TrueMethyl oxBS Module
Methods for performing comprehensive epigenome-wide association studies that analyze both 5mC and 5hmC levels
How researchers applied TrueMethyl oxBS to detect an abnormal epigenetic signature in multiple system atrophy (MSA) patients
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