#ProstateCancer Clinical Trials: The Benefits and Risks | #MarkScholzMD #PCRI

FREE In-Person | March 11 | Los Angeles, CA

Clinical trials are commonly considered to be the "last resort" for patients who have run out of conventional treatments; however, clinical trials are available for all stages of prostate cancer and may sometimes offer patients early access to treatments or protocols that could provide them value. However, there are a lot of factors for patients and doctors to consider to determine if a clinical trial is appropriate -- for example, would it compromise the patient's care if they were assigned to the control group? Are there proven treatments that would be more appropriate than what is being investigated? And so forth. Clinical trials are the gold standard for assessing whether theory translates to practice, finding optimal dosages, and evaluating the safety and efficacy of a drug, but patients and their doctors may want to be careful that the patient's level of care is not compromised by the pursuit of general knowledge.

0:34 What is a clinical trial? Which kinds of patients should be aware

3:06 Can you explain the three phases of clinical trials? Phase I, II, and III?.

4:53 How do patients find good clinical trials?

5:31 Which factors should patients consider when evaluating a clinical trial?

6:15 At which disease states should men consider clinical trials?

6:56 Is a clinical trial necessary for treatments with obvious benefits?

8:46 How can a patient know that a clinical trial is not sacrificing their individual level of care when joining a clinical trial?

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The information on the Prostate Cancer Research Institute's YouTube channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.

#ProstateCancer #MarkScholzMD #PCRI

[grride]

Thank you for another valuable and pertinent video. My local oncologist recently asked me to contact my Stanford University doctor for any available clinical trials available for my PC profile. This video definitely helps in understanding how this all works. Much appreciated. 👍🏽

[John-the-Bass]

Very helpful, thanks for the information. You are a fantastic support.

[jimk]

It is a valid point that "new" is not necessarily better, although a well-conducted clinical trial hopefully provides useful information to the medical community and, by extension, to future patients. Unfortunately, many clinical trials do not demonstrate superiority of the experimental treatment to the current standard-of-care.

[kazimgumus]

Great presentation, thank you for doing this!!!

[robbujold]

I have unfavorable intermediate risk PC and will be getting radiation therapy + ADT. I have an opportunity to enrol in a clinical study (NRG GU-010) that would use my Decipher score to determine if ADT de-intensification is adequate (for those with a low score) or, alternatively, if intensification with a second hormone drug offers additional benefit (for those with a high score). I’m hoping for a low score and to get in the study arm that will not get any ADT. I’ve heard Dr. Scholz mention that he is not such a big fan of Decipher. I’m wondering if you could discuss the different genomic tests and why Dr. Scholz might prefer one over another.

[frederickrich]

Would you consider me needing 2 Yr of prostap hormone treatment with gleeson 8, 4 + 4 psa 7 T3a MO No, 32cc prostate 69 years old, I also had 20 Radiotherapy sessions, my psa is now 0.01, I am recovering my libido now after finishing my hormone treatment after 18 months which was 6 months early due to my low psa of 0.01, any thoughts much appreciated. Thank you for all your valuable informative videos.

[pavelvenkov]

Where I can get a list of all available clinical trials on PC?

[thatguy]

Is radiation treatment the way to go 18 years after a prostatectomy and a psa of 1.4

PSMA scan showed a tiny bit of psa at the area where the prostate used to be.

Are there better alternatives?
Not crazy about radiation treatment.