What’s Different About the Johnson & Johnson COVID-19 Vaccine?

It’s official: The Johnson & Johnson vaccine has been granted emergency use authorization by the US FDA, joining the ranks of Moderna and Pfizer. Here's why this decision could be a game-changer for vaccine distribution.

While not as high as Moderna’s and Pfizer’s 94 and 95% overall efficacy, this vaccine was found to be 85% effective against severe disease, regardless of the region or what variant it is exposed to. What’s more, it requires a single dose to work and doesn’t have specialized freezers — two attributes which could be a MASSIVE game changer for expanding access across the globe.

Not only that, but the J&J vaccine is more durable than many of its counterparts, particularly those developed by Moderna and Pfizer.
Also, unlike mRNA based vaccines, which are incredibly fragile and require cold storage to protect from damage, the J&J vaccine doesn’t require the same ultra-cold storage to stay intact. In fact, it can keep in a regular refrigerator for up to three months.

So, how exactly did J&J bring this all together? Well, it all has to do with how its vaccine is formulated. Similar to the University of Oxford’s Astrazeneca vaccine and China’s CanSino vaccine, it uses a modified adenovirus as its vector: specifically, Ad26. That adenovirus is going to induce certain kinds of protective responses that will allow this little piece of COVID that we stuck into it to have a much greater effect. Once the little piece of COVID is inside the cell nucleus, its DNA code for creating a spike protein gets translated into RNA. The cell can then ‘read’ those instructions to make copies of the virus’s spike protein. These copies trigger the body’s immune response, helping it to become familiar with the virus and develop a plan of attack, should the two ever meet again.

#COVID #COVID-19 #Coronavirus #vaccine #vaccines #JohnsonandJohnson #seeker #science #elements

Read More:

J&J’s single-dose COVID vaccine raises hopes for faster rollout
"US regulators have authorized Johnson & Johnson’s vaccine — which does not require a booster shot, and could simplify the logistics of mass vaccination."

Why The Johnson & Johnson Vaccine Has Gotten A Bad Rap — And Why That's Not Fair
"First of all, I want to make the case that the J&J vaccine is not a lesser vaccine. And second is we absolutely should not be distributing these things based on socioeconomic status or any of those things."

What are Adenovirus-Based Vaccines?
"Adenoviruses are considered excellent vectors for delivering target antigens to mammalian hosts because of their capability to induce both innate and adaptive immune responses. "

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[DstumpJ]

"No more tears." Could be very accurate.

[echln]

I hope it makes me smell like their baby products

[alec]

Johnson & Johnson: a Family Vaccine

[lflash]

Lol didn’t Johnson and Johnson get sued for their baby powder lol....

[brian]

The difference is, it's Belgian/Dutch, developed and produced here in the Netherlands and Belgium.

[sebholding]

In fact you can't compare it to the other vaccines in term of efficacy rate because it was only tested for one shot (and the efficacy at this first shot appear superior or similar to the others at the first shot). Its currently being tested with two shots.

[Diedder]

0:21 66% effective in preventing severe diseas
0:34 85% effective against severe disease
So which is it now? Does the first percentage not show efficacy but something else?

[TheCarnivalguy]

“Babies are our business; our only business”. Wait. I think that’s Gerber. 😂

[leveretth]

1:24 Couldn't the '8, 000 747 airplanes' figure be reduced to just, say, 1, 000 747s doing eight round trips (or sixteen round trips for double dose vaxxes)? Certainly, that 8, 000 figure doesn't mean that many 747s must fly every day from now until all the vaxxes are delivered and administered, does it?

[adolfinagamingroblox]

cant wait for the nike and adidas vaccines

[christopherconkright]

I saw J&J is studying a booster after 2 months that gives 95% effective

[Martial-Mat]

I thought the air industry was DESPERATE for business. Surely they should LEAP at the prospect of 16, 000 flights?

[Dwamak]

As a person who played a lot of XCOM 85% is just not enough. :)) But also we need to give it a shot ;)

[yvonneshealey]

I get my J and J Tuesday 4/12/2021. I hope I have no side effects.

[FateRuinsme]

No difference I'm not getting either 1

[Luxcium]

The lower effectiveness vs. the one doses required cancel each other in people’s mind so I think that it’s something that will help the vaccine to be the first choice for many people... But I want to travel to places where no one have yet received vaccine so efficacy is slightly more of a concern for me... but in my province (Québec 🇨🇦) they decided that a second dose would be 90 days after a first which would delay my travel up to 3 more months so given the hypothetical situation where I could choose my vaccine I don’t know which one would be the best choice in that context...

[KiltedJock]

Johnson & Johnsons track record is horrendous... I wouldn't trust them with blowing up a balloon

[loryndabenson]

So in the event the Janssen booster shot becomes ineffective in certain populations, would it be safe to get one of the other vaccines as the booster shot after getting Janssen as the initial vaccination?

[oscarv]

A lot of attention has been giving to the vaccines and rightfully so but can you guys please make a video about new treatments that can also help with death and hospitalization

[chisehwechalamba]

How likely do you guys think it'll be that this pandemic could last a couple more years? As in people would need yearly vaccines to compete with new strains.