The lifecycle of SARS-CoV-2

What happens to the cells in our airways during a coronavirus infection? In this animation for Maastricht University we follow the full SARS-CoV-2 replication cycle, going from initial infection all the way through to new virus particles being released from the cell.

Chapters:
00:00 Healthy respiratory cells
00:25 Components of the virus
01:06 Variants
01:31 Entering the host cell
02:15 Making viral proteins
03:00 Viral RNA knot
03:55 Double membrane vesicles
04:14 Replicating viral genome
04:48 Making more viral proteins
05:09 Creating new viral particles
05:49 Release from the cell

Correction:
01:24 This should be D614G

[PhosphoUk]

The mutation that is present in each variant of concern should read D614G instead of D416G.

[wycliffe_ndiba]

This is an incredible video. Explained very well and beautiful animations, if they're sims I can only imagine how long it took to simulate

[davidscott]

This is astonishingly well done, as I'm recovering from COVID now, I am amazed how our bodies eventually, hopefully, stop this remarkable process from continuing.

[expandknow]

The best explanation and animation that I saw on this topic until now. Shame that there's this distracting background music over it

[WMiller-yeru]

Gorgeous video and I love the music. But as an expert on ribosomal frameshifting, it is a bit incorrect. The "knot" is actually just a pseudoknot. I get simplifying it to just say knot, but that's kind of a big difference. No knots in RNA that I know of. More importantly, the pseudoknot, doesn't cause the ribosome to stop, it actually enables it to keep going by pushing the ribosome into a different reading frame and not seeing the stop codon which is actually what makes the ribosome stop most of the time. Still, I will show this to my virology class.

[EtelCarrada]

Wow! Amazing animation. Excellent job. 👏🏼👏🏼👏🏼

[foodi]

Excellent job in both scientific and artist work. Well done :)

[alyssafrazier]

this video just saved my genetics grade

[EvntHorizon]

Astonishing detail here, thankyou for sharing this. It's my understanding that some of the intracellular processes described in the video happen much faster than shown here. Is that right, or have I misunderstood this? Either way, it's chilling to see how ruthless viral reproduction is!

[SuperSquark]

A mechanism for all disease. Increased oxidative stress leads to oxidation, evidenced as Inflammation.
A healthy cell is repleat in electrons and can therefore only be oxidised.
Its a hypothesis.

[ananyapaul]

Animation and concept both was top-notch. 👏👏👏

[selenba]

Hi, thank you for your video. The animation is lit ! I was wondering, if the dmv is made from the host cell membrane, does that mean the vesicle ends up outside the cell? Then, when the subgenomic RNA exits the dmv thought it's pore, it needs to re-enter the cell thought another pore too?

[SilviaBongiovanni-vlxm]

I feel like I saw a dramatic movie, really nice video

[SjonSjine]

Compliments! Q: what software did you use?

[vacantstairs]

shouldnt we consider what your aunts insurance broker said on facebook about how it works before we say for sure?

[davidbahry]

This video contains an error, but it's an educational one. The animation of spike cleavage would better fit the original SARS than SARS-CoV-2.

In the original SARS, both the first cut (S1/S2) and the second cut (S2') happen at the surface of the target cell about to be infected, e.g. both might be done by the cell-surface protein TMPRSS2. But for SARS-CoV-2, the S1/S2 cut was already done well ahead of time, by the soluble protein furin in the Golgi apparatus of the cell where the virus was made. By the time the virus got out of the origin cell and towards the target cell, its S1 and S2 were already cleaved and already only loosely non-covalently bonded. Reference: Jackson et al., 2022

[jeanpaulchristian]

None of the proteins are labelled. For instance where is the Furin Protease???

[jardonspark]

thank you so much this video will help with my research, could I ask what is the piano melody in this video, sounds like something Hannibal Lecter would listen to

[matheusmf]

Dendritic cells: hey boss there is something happening here, over
T-CD4: Can you bring me some clues of what is going on? Over
Dendritic cells: look what I've found, they are transforming our citiziens into zombies
T-CD4 to T-CD8: hey Charlie, sniff this, good boy, good boy, seize them!

[KNS]

man i think my mom just died to sars cov 2 today cuz shes not waking up on the bed and she got sars cov 2 4 days ago 😭