The Coronavirus Replication Cycle

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[emmathomson]

Nice video - the receptor of the COVID-19 SARS-CoV-2 (which binds to the S1-CTD of spike) is ACE2. I think the video has likely been adapted from the replication of the related betacoronavirus MHV (mouse hepatitis coronavirus) which binds to CEACAM1 (via the S1-NTD of spike)

[Jstar]

Great video!
I was struggling to understand what on earth subgenomic mRNA was and how it was generated, this video has made it really clear.

[sepehrzadehmorshedbeik]

I am currently working on my final year pharmacy project. This video helped me a lot in understanding the concepts of viral replication!!

[timopihlajamaki]

A well made video, but it does have quite a few errors. First of all, as other people have noticed too, the receptor for SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2). There's also evidence that SARS-CoV-2 can use neuropilin-1 (NRP1) as an entry receptor too.
The other error is in transcription of subgenomic RNA (sgRNA). In your illustration you state that -ssRNA is used as a template, and therefore transcription would happen in 5'-3' direction. Translation happes in 5'-3' direction, but transcription happens only in 3'-5' direction.
This is why Nidovirales (including CoV) use +ssRNA as a template to produce -sgRNA which is then used as a template for +sgRNA, and that is used as mRNA for translation of structrural proteins and accessory proteins. You got the principle right, but I guess you mixed a few things on the way. :)

[zuhairreza]

I am taking Virology, Bio 420, as a second-degree undergraduate at my college, the City College of New York, in New York, NY., and this was very, VERY helpful. Thank you SO much for this amazing video that explains the workings of the Coronavirus easily and in a simple way. Best wishes!

[moethekhine]

Thanks a lot. I was struggling so hard to understand this mechanism as I didn't understand it at all during lecture at school. Your explanations are very clear and easy to understand. Sincerely thanks.

[scottclark]

Ok I thought the SARS CoV 2 (COVID-19) initially binds to ACE2 receptors?

[jonicrow]

finally, some more in-depth explanation on the topic. Thank you. I thought the receptor was ACE2, though. I think CEACAM1 (also called CD66a) is an immunoglobulin which is also used for cell invasion by some coronal Hepatitis Viruses.

[jimayla]

I've found this video useful.... I have Virology exams to write next week. Thank you

[jycapuras]

Very clear explanation and illustration... Thank you very much!!!

[jeffleuvenink]

So I was learning for my exam and I didn't quite get the discontinuous transcription part, but this video really helped so thanks!

[marcmatossian]

Binding to the ACE2 receptor has been linked to NRP1 and TMPRSS2 as possible cofactors and even independent of ACE2 viral binding. Although the ACE2 receptor is commonly seen as the necessary component for viral infection, research is being published to suggest NRP-1 as a possible binding site for the cleaved portion of the Spike protein.

[matsalme]

Lucid and easy to survey. Wonderful voice of the narrator.

[aldrvxc]

*where did you get these **2:04** and **4:10** pictures? I checked the link on description but i didn't find it. Could you give me the articles link here? Thanks a loot btw 🙏✨*

[zeqxpyl]

Clear, concise and educational video for a non biologist to understand the replications of the virus. Hope can watch more videos such as virus mutation (delta), vaccination working mechanisms.

[doodoobearlove]

thanks for explaining so clearly n making sense for details as well. this is really helpful! thanks a million

[JohnDoe-vsqf]

What's interesting is that the diagram you are using at 3:40 is showing that the sg mRNAs are coming directly from the full antisense (-) genomic RNA strand that is synthesized from the initial sense (+) genomic RNA, yet the diagram used at 8:48 was taken from Marle et al.'s 1999 paper, which contends a completely different mechanism for the sg mRNA synthesis. In their paper, they contend that the sequence goes as follows: sense (+) viral genomic RNA, to discontinuous antisense (-) sg RNA synthesis via RdRp 'jumping', to (+) sg mRNA synthesis finally. This was clearly outlined in Figure 5 of their paper. Therefore, it seems you are presenting two different mechanisms of sg mRNA synthesis. I have watched a lot of your videos and absolutely love them, so I am not trying to be difficult.

[رعدشاكر-جخ]

Very useful video, thank u very much 🌹

[frediksterner]

Excelent Describing, The best video that I watched

[diribataddeselegesse]

Great! difficulty is how to block only one step of the triplication