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Learn how to Encapsulate Hydrophobic API in PLGA
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This webinar hosted by Dr. Pavel Abdulkin uses Dolomite systems to explore the most suitable microfluidic methods for encapsulation of the hydrophobic active pharmaceutical ingredient (API) in PLGA particles. Focus of this webinar was to review the difficulties of standard methodologies and how users may overcome it with microfluidic technology to achieve encapsulation efficiencies of almost 100%.
1) Introduction: 0:00 - 1:35
2) Microfluidic technology & how it works: 1:35 - 3:45
3) Droplet / particle production methods: 3:45 - 6:32
4) Controlling droplet size: 6:32 - 8:15
5) Dolomite systems including scale-up with Telos: 8:15 - 10:05
6) PLGA microparticles: 10:05 - 15:20
6.1) Particle formation process & direct encapsulation: 10:05 - 11:35
6.2) Solvent extraction process: 11:35 - 13:15
6.3) Multiple emulsions: 13:15 - 15:20
7) PLGA nanoparticles: 15:20 - 22:45
7.1) Particle formation process: 15:20 - 16:43
7.2) Methodology 1 - Micromixer chip: 16:43 - 18:50
7.3) Methodology 2 - Hydrophobic chip & results: 18:50 - 22:45
8) Emulsion stabilizers: 22:45 - 23:35
9) Conclusions & additional information: 23:35 - 24:20
1) Introduction: 0:00 - 1:35
2) Microfluidic technology & how it works: 1:35 - 3:45
3) Droplet / particle production methods: 3:45 - 6:32
4) Controlling droplet size: 6:32 - 8:15
5) Dolomite systems including scale-up with Telos: 8:15 - 10:05
6) PLGA microparticles: 10:05 - 15:20
6.1) Particle formation process & direct encapsulation: 10:05 - 11:35
6.2) Solvent extraction process: 11:35 - 13:15
6.3) Multiple emulsions: 13:15 - 15:20
7) PLGA nanoparticles: 15:20 - 22:45
7.1) Particle formation process: 15:20 - 16:43
7.2) Methodology 1 - Micromixer chip: 16:43 - 18:50
7.3) Methodology 2 - Hydrophobic chip & results: 18:50 - 22:45
8) Emulsion stabilizers: 22:45 - 23:35
9) Conclusions & additional information: 23:35 - 24:20
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Learn how to Encapsulate Hydrophobic API in PLGA
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