Pharmacology - ANTICOAGULANTS & ANTIPLATELET DRUGS (MADE EASY)

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Anticoagulants, commonly referred to as blood thinners, are drugs that prevent or reduce coagulation of blood, prolonging the clotting time. Antiplatelet drugs, also known as a platelet aggregation inhibitors, decrease platelet aggregation and inhibit clot formation. These drugs play an important role in the treatment of various disorders such as myocardial infarction, thrombotic stroke and venous thromboembolism. This pharmacology lecture covers topics such as pathophysiology of blood clot formation and platelet function; activation, aggregation, cross-linking; ADP receptors, glycoprotein IIb/IIIa receptors, cyclooxygenase-1 (COX-1) enzyme, fibrinogen, fibrin mesh, coagulation cascade; intrinsic & extrinsic pathways, clotting factors, antithrombin, heparin induced thrombocytopenia, INR, plasmin, and plasminogen; mechanism of action of platelet inhibitors, anticoagulants, thrombolytic agents, and drugs used for treatment of bleeding. Drugs mentioned include; Aspirin, Clopidogrel, Ticagrelor, Ticlopidine, Prasugrel, Abciximab, Eptifibatide, Tirofiban, Heparin, low molecular weight heparins; Enoxaparin, Dalteparin, Protamine sulfate, Apixaban, Rivaroxaban, Univalent & Bivalent direct thrombin inhibitors; Argatroban, Dabigatran, Bivalirudin, Desirudin, Warfarin, Vitamin K, Alteplase, Reteplase, Tenecteplase, Urokinase, Streptokinase, Aminocaproic acid, Tranexamic acid.

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0:00 Platelet plug formation
2:04 Platelet aggregation inhibitors
5:34 Coagulation cascade
7:38 Anticoagulants
12:03 Warfarin
14:11 Thrombolytics

[SpeedPharmacology]

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[Samahn]

Update: an antidote for apixaban and rivaroxaban is now available: Andexanet alfa. Came out in 2018, one year after this video was uploaded.

[sarahll]

since i was pharmacy student i used to watch your videos before mid & final exams and it help me to remember things & make it easier
now i'm officially graduated pharmacist but still love watching your videos😅
so i want to say thank u so much for making pharmacology easier on me ❤️🧸

[alexnelson]

It's nice to have a diagram of the cascade and then interject each drug class where it acts. Thank you! This is how all topics should be taught by all teachers!

[xueyingzhu]

Coagulation cascade are the ones I found hardest at med school and it was a pain to revise when comes to finals then I forget about it. Now I'm preparing for core training exams and actually find this video more helpful than ever. I never understood this topic any clearer (I guess with more clinical experience it also helps to understand bit more). Thanks so much for making this video.

[roxana]

This was perfect from beginning to end. Information logically categorized, great talking speed, use of graphics that helped anchor understanding... bless you for taking the time to make this!
First time seeing your videos, instantly subscribed. Looking forward to watching the rest of your videos through Pharmacology class!

[anhduong]

Please keep making those videos, it was organized, simple, and really straightforward. You just save my 5-hour listening to recording lectures. Thank you so much

[ganeshramakrishnan]

this video is absolute gold. thank you so much for taking your time to make this, you deserve an award.

[Pacrac]

The overall video was great. I would just like to note that the Mechanism of Action for Fondaparinux is incorrect. Fondaparinux actually binds to Anti-thrombin III and potentiates its selectivity and affinity for Xa. Fondaparinux is in fact Anti-thrombin III mediated which is what distinguishes it from the direct Xa inhibitors (ApiXAban, EdoXAban. RivaroXAban and BetriXAban) which are not Anti-thrombin 3 mediated.

[leongkeenwai]

Thank you for the great video! The reversal agents discovered after this video was made: for apixaban it’s andexanet alfa, and for dabigatran it’s idarucixumab.

[sasori]

I was struggling with this for hours then I found your video
This is the freaking best!

[Ak.shafi]

I'm officially graduated pharmacist still love to watch ur videos, thanku so mch for making pharmacology easier

[swashnaavneeta]

Oh my god! I was literally waiting for the upload of video on this topic. Sir, You make learning process in pharmacology so simple and easy to understand. I owe all my good marks to your lectures! Thanks a ton❤

[chiamakadorisanyaneji]

Amazing video. I have been struggling with this topic but this has made it very easy for me . Thank you.

[Dazzletoad]

I am self studying some medical subjects without requisite chemistry and without other helpful pre medical information.

Despite the brain damage I got from this, your lecture has really helped me understand the activity of aspirin in coagulation.

Huge thanks for uploading this, it has been a great help to me 😎

[belquees]

WHO KNEW IT WAS THIS EASY!!! I can't thank you even for saving my life

[bibisart]

thanks for keeping your lectures short, simple and to the point

[DrHistoryV]

just a quick errata; eloquis/(apixaban), xarelto (rivaroxaban) have an FDA approved reversal agent


"Andexxa, the first factor Xa inhibitor antidote indicated for patients treated with rivaroxaban (Xarelto) and apixaban (Eliquis), when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding."

[raymond]

Great summary video! thanks for the post. It was very helpful. I like that you give examples of all the drugs in each class and their mechanisms with visuals. This helps to solidify the information for visual learners.

[theglycoprotein]

I have just discovered you and u have no idea how grateful I am.