Chronic Inflammation (Lecture 1)

What Does Chronic Inflammatory State Mean? (Lecture 1)

Although innate immune stimuli contribute to chronic inflammation, the adaptive immune system is usually also involved and cytokines produced by T cells are powerful inducers of chronic inflammation
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 94). Elsevier Health Sciences. Kindle Edition.

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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.


URL list from Wednesday, May. 18 2022

DrBeen: Medical Education Online

Chronic Inflammation - StatPearls - NCBI Bookshelf

Inflammation - Wikipedia

Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain - PMC

Frontiers | Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals | Immunology

[karenramnath]

It was indeed a very useful 52 minutes. I learned a lot.
I’m not a doctor, just a seamstress. But I enjoy listening to your lectures while I am sewing.
Thank you for putting it in a way that is easy to understand.

[harashigomari]

Amazing how much more interesting the world becomes when you've made the effort to learn the biology

[jcdilgernutrition]

Great lecture! Chronic stress is a huge driver of inflammation in the body

[DrZ-notthatone]

Dr. Mobeen- I love these deep dives into subjects lesser understood! I’m looking forward to the next chapters!

[carolhurley]

I have become extremely sensitive to gluten. I was miserable for 18 months with a rash that all Dr's attributed to gluten. I was not ingesting any(I thought) gluten. Of course it coincided with the virus shut down of this country so getting help was difficult. On of my daughters from another mother who studied to be a pharmacy tech helped me. She discovered that a medication I was taking had a gluten filler. 2 days after ceasing the medication the rash abated. My body has rewarded me by losing weight for the first time in years. I'm a real believer in chronic inflammation and how our body reacts. I have dry eyes and mouth but not sjogrens by testing and biopsy. Thankfully I have Dr's that help treat these conditions despite the negative testing. I think my body's immune system is so ramped up that covid never had a chance. Recently tomato in any form has started to effect me in an allergic manner, sneezing, etc. Interesting Dr B mentions tomatoes. Thank you for this lecture! It explains what I now think after my experience.

[ralphhancock]

Good to see this discussion started. Please incorporate the role of the possible chronic inflammation caused by chronic exercising. I put in about 8 hours of exercise per week, and would like to know how all that exercise helps or hurts.

[mikhaellevin]

I have had Myalgic Encephalomyelitis since age 7, and have now had 5 acute Covid infection. I see “long Covid” dept in my hospital finally, …..my first infection was March 13th 2020. So it’s been a bit of a wait. I purchased your collection. I am not college educated. The highest education I have is a 2 year graphic design degree.

Now I know about the build up about angiotensin2 (my bp is now 160/120. I’m on medication ….for example) and self ace-2 antibodies, (I ran a fever for 8 months. I could be in my feet 10 minutes 3 times a day for over a year) and monoclonal antibody had to be bought outside the medical system because only percent of monoclonal antibodies have actually gotten to the Immunocompromised. I knew for a year and a half that what I needed for long Covid. People with ME don’t fully get rid of anything.

Evusheld is by lottery and only for people getting organ transplants or active chemotherapy with co-morbidities. I have small vascular damage with microbial infections, and got my 4th infection during the biopsy for scleroderma type damage from the the other 3 cases.

It’s been fun! You’ve been an inspiration. Thank you.


Wow. Wow. I just finished this. My ears and the back of my neck have been covered in impetigo and fungi since having Covid damage. Ok. So that triggers TNF alpha as well….and IL 1? Or is it just TNF alpha? There is intercellular fluid. I mean in my tests…

They are either gonna love me or hate me at the dr. Tomorrow.

[cherryb]

Dr Been that was an amazing informative lecture. I pray that you will be given the opportunity to give these gifts to humanity to all those who need it. Thank you so much.

[mariannereno]

Thank you! Dr. Mobeen. This is a huge issue. Almost has taken me down. I'm working on improvement. Extremely difficult. Histamine intolerance.

[amiehegeman]

Thank you so much for covering this topic! I look forward to the rest of the series.

[leslyrae]

This is great, thank you! Will you also be covering immune memory. Recent research is proving what some of us have suspected all along, showing that these inflammatory responses can continue long beyond the original need for the inflammation. For instance the pathogen is gone but the immune response and inflammation continues.

[irinachenkova]

Excellent lecture! Very simple and very sophisticated explanation. Thank you for your gift!

[andreabolding]

Thankyou so much, loved your explanations that constantly reference where your fact sits in the global picture. E.g. inflammation is a process of the Innate arm of the immune system. This is real teaching. I have been a nurse for 30 years and your explainstions are making all the little peices of amazing detail we learn over the years, making it all fit into the bigger context.
Thankyou

[Kathleen]

Thank you very much Dr Been. I understand this subject so much better than what I learned in my A &P.

[motomarty]

Dr. Been. Your excellent diagrams go hand in hand with your superlative ability to convey complex medical science to the ordinary listener.

[incedofortis]

Love your work, thank you for your time and dedication.

[jeannieneuser]

Love love love this!! 💖
Can't wait for the next one!! 🎉

[drl]

Thank you for covering such an essential topic for health in such a great way.

[jp]

this video has been a HUGE eyeopener. I'm extremely interested in lipids / lipidology (as a consumer not a professional), understood that inflammation plays a part in atherosclerosis but didn't understand the mechanism. if I understood this correctly TNF/inflammation causes the tight junctions between endothelial cells to open allowing in WBC and ApoB contained lipids ? TNF/ILx also upregiulate ICAMS and VCAMS ? Wow -- Im going to have to watch this again ... extremely excited to see the next ones in the series !!!! ... love a video on atherosclerosis/inflammation from a TNF/ILx perspective THANK YOU ... the only negative is that Im going to haver to spend 2 weeks on google now that you've armed me with the relevant key words and phrases !!! (I spend a LOT of time on medical/logevity medical education - and this may be THE most important video Ive seen).

[frankporter]

Thank you. Discussion of this subject is long overdue.