anti-aging antibodies?

There’s only one alliterative phrase i like more than 'the sheekey science show', and that’s 'anti-aging antibodies'. now, as it happens, one thing i spent a lot of time working on this year is antibodies. Antibody, make me feel this way. now while i cannot tell you yet what i was/am doing, i can tell you about two recent science stories that exploit antibodies to extend mouse lifespan. Firstly, i will bring your attention to this paper - immunotherapy targeting isoDGR-protein damage extends lifespan and then we’ll look at this paper that came out last month - Inhibition of IL-11 signalling extends mammalian healthspan.

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TIMESTAMPS:
Intro - 00:00
Antibodies - 00:45
Inhibiting protein damage - 02:15
Inhibiting IL-11 - 05:20

REFERENCES

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

[TheSheekeyScienceShow]

apologies for the lower audio quality this time - was a combination of noisy circadas and my post-karaoke voice :D - also, i think ~1:20 i say antigen when i meant antibody!!!

[jorgeroman]

Another paper closer to mice inmortality!

[dennisschott]

Thank you for your very thorough explanation on practically a layman's level. I always look forward to what you have to introduce to us.

[xtmillsx]

Thank you, that was concise, information dense, and enlightening. Exactly what I seek in this medium.

[paulhindle]

Thanks Eleanor, that was very helpful. Until they can offer me a prescription Il-11 inhibiter I have been busy making a list of various foods and supplements that may act as suppressants. My list so far includes Omega 3s, Lutein, curcumin and of course exercise.

[brewhog]

Awesome! I've been hoping you would cover this for a while (il-11). Thank you!

[peterz]

Thank you! So, I wonder if hsCRP, easy to measure, correlates with IL-6 and IL-11. Seems like IL-11 is more evidence that chronic elevation of inflammation is pro-aging. And doing things that keeping inflammation low, except when needed, should be part of an antiaging strategy. Mean time I will be checking IL-6 and hsCRP.

[a.k.]

Very interesting, thank you. Just curious, but would fasting and autophagy help as well with the protein clean-up?

[Santa-nyyp]

First, we make them immortal. Next, we make them smarter. I hope our new Mice Overlords are kind to us.

[i_accept_all_cookies]

Could this be a "laboratory artifact"? While blocking IL-11 might extend lifespan under ideal conditions, it could potentially reduce resilience to certain types of stress or injury.

[pjaworek]

I hope so. 10% for Taurine, 10% for glynac and 25% for this and I'm seeing 200 years old!!!! Well almost. I need another 20%. Maybe hbot will give me a few. Then there's Yamanaka which I'm not hearing about lately.

[gdok]

There must be much excitement in the mouse community! I think this looks promising for humans too. We are getting closer to anti-aging therapies. The part of the AI community that focuses on AlphaFold-3 and its astonishing abilities in unlocking the secrets of protein folding are predicting LEV (Longevity Escape Velocity) by 2030. That may be optimistic, but I think we are closing in the aging problem at an ever accelerating pace. It will truly shift the medical/healthcare paradigm.

[johnthefisherman]

Il-11 is already in clinical trials. The video did not do it justice.

[Kevin_Street]

Thank for this most interesting video! I feel dumb asking what may be an obvious question, but instead of continuously taking antibodies, could this treatment be made into some sort of vaccine?

[brianmahoney]

thanks for this useful summary. im so confused about david sinclaires big thing where he accelerated the apparent age of mice, is that real or what? a lot of mumbling about how it isnt real but i havent seen anyone debunk it. and its irritating because it would be a big deal if it were actually real.

[piotrcharkot]

love your videos :) what would be the cost of such immunotherapy ??

[kx]

Repeated dosing that's just the feature that can bring it to market

[tkorte]

Cataracts are protein buildup in the lens. Could specially designed antibodies remove those proteins?

[Mastervitro]

Are there any known "anti-aging" gut bacteria?

[brianmahoney]

why are biochemists so insanely quite about david sinclair? it really frustrates me how scientists fall into this mental trap of thinking the best thing to do is to never say anything, good or bad. the world needs scientists to just say what they think. silence does more harm than good.