USMLE Respiratory 4: Physiology - V/Q Mismatch and A-a Gradient

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More lung physiology! The big overarching message today is that not every single molecule of oxygen that you breathe in will go into your blood! Now there are several ways we can look at this. The first way is measuring VQ ratio. Ventilation is measured as V, and perfusion is measured as Q. Now ideally, we'd want it to VQ = 1, but instead it's 0.8. Now the apex of the lung has more ventilation and VQ is 3. At the base, it is 0.6 and thus the average is about 0.8. You can get this closer to 1 by exercise or by lying down. Now how can lung pathology affect our VQ? Let's take it to the extreme. What if there is no ventilation? Then V = 0 and thus V/Q is close to 0. This does not respond to oxygen therapy. If perfusion reaches 0, then P = 0 and thus VQ = infinity. This does respond to oxygen therapy.

Now another way to illustrate this point is via the A-a gradient. This is the difference between the oxygen content in your alveoli and your arteries! Normally the gradient is less than 15 meaning the lung is normal. Thus if a pt has hypoxemia or hypoxia but they have a normal A-a gradient, then the problem is outside the lungs! Make sure you look at my notes to see the equation and a practice question!

Done!
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Great Videos!!!! I really love how you break down the concepts.

sarshize
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Normal A-a gradient (correct with O2) 
-reduced PiO2 (high altitude) 
-hypoventilation (CNS depression, morbid obesity) 
INCREASED A-a gradient (correct with O2) 
-Diffusion limitation (emphysema, interstitial lung disease)
-V/Q mismatch (small PE, lobar pneumonia) 
INCREASED A-a gradient (not correct with O2)
-large intrapulmonary shunt (diffuse pulmonary edema)
-large dead-space ventilation (massive PE, RtoL intrathoracic shunt)

ShanilR
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Hi! Love your video, I wish you were around when I was in medical school. Do you do private tutoring?

AdNG
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Great videos. Seriously. Thank you so much

drarchitgupta
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Why PAo2 increase in lung disease. I don’t get it.

Yasso
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want is Arterial A Gradient Normal range: 17.0 - 31.0 mm hg

richardwhittington
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